Adoptive immunotherapy involving genetic modification of T cells with antigen-specific, chimeric, single-chain receptors is a promising approach for the treatment of cancer. To determine whether gene-modified T cells could induce antitumor effects without associated autoimmune pathology, we assessed the ability of T cells expressing an anti-Her-2 chimeric receptor to eradicate tumor in Her-2 tr...

In her book Risking Who One Is, Susan Rubin Suleiman asks, “Why ... write? Why tell the tale?” and reflects further that “although the double bind of ‘having to tell, having to fail’ belongs most excruciatingly to those whose [stories] are the most painful, the most unrepresentable, perhaps it is inherent in all autobiographical writing. No one will ever experience my life as I have, no one wil...

AIM OF THE STUDY To determine whether the expression of HER-3 influences the survival of HER-2 positive patients with breast cancer (BC). MATERIAL AND METHODS In the present work, the expression of HER-3 in a group of 35 HER-2 positive patients with BC was studied by performing immunohistochemistry (IHC) in formalin-fixed paraffin embedded tissues. RESULTS Higher HER-3 status if estimated b...

At a 50-acre farm in the California Central Coast1 region, I spoke with Alejandra, who personifies the ideal outcome of the beginning farmer movement. Coming to the United States in the mid-1980s, she described herself as the latest of “three generations of migrant farmworkers” from the Mexican state of Guerrero, following in the footsteps of her father and grandfather, who emigrated for contra...

Gisela Telis was recognized for making her mark ? online, on the radio and on television ? as a content producer for Arizona Public Media [4]. Telis has received Emmy Awards for her work bringing attention to mental health issues. In her nomination letter, Jack Gibson, director and general manager of Arizona Public Media, wrote that Telis' work "exemplifies the best and most meaningful aspects ...