The Fc-region of immunoglobulin E (IgE) comprising C epsilon 2, C epsilon 3, and C epsilon 4 domains is sufficient for binding to the alpha chain of the high affinity IgE-Fc receptor (Fc epsilon RI alpha). In order to identify the smallest Fc fragment capable of binding to the Fc epsilon RI alpha with high affinity, various regions of the IgE-Fc molecule were expressed in COS cells and investig...

The miscoding potential of N2,3-ethenoguanine (epsilon G), one of the carcinogen vinyl chloride adducts to DNA bases, has been examined by copying of poly (A, epsilon G) templates with DNA-dependent RNA polymerase and reverse transcriptase. In contrast to the results previously obtained with poly (C, epsilon G) templates where epsilon G acts as G and A, in poly (A, epsilon G) templates epsilon ...

Epsilon is an extensible platform of integrated and task-specific languages for model management. With solutions to the 2011 TTC Hello World case, this paper demonstrates some of the key features of the Epsilon Object Language (an extension and reworking of OCL), which is at the core of Epsilon. In addition, the paper introduces several of the task-specific languages provided by Epsilon includi...

Epsilon technique cannot learn from training patterns with a contradiction | i.e. two or more training patterns have identical inputs but dierent outputs. These training patterns are not 100% satisable and the Descending Epsilon technique will not be able to reduce the value of epsilon beyond a limit. Secondly, the Descending Epsilon technique takes more cycles than normal back-propagation sinc...

Let G be a Carnot group. We study nonlocal diffusion equations in domain $$\Omega$$ of the form $$\begin{aligned} u_t^\epsilon (x,t)=\int _{G}\frac{1}{\epsilon ^2}K_{\epsilon }(x,y)(u^\epsilon (y,t)-u^\epsilon (x,t))\,dy, \qquad x\in \Omega \end{aligned}$$ with $$u^\epsilon =g(x,t)$$ for $$x\notin \Omega$$ . For an appropriated rescaled kernel $$K_\epsilon$$ , we apply Taylor series development...

The initiation of reverse transcription and nucleocapsid assembly in hepatitis B virus (HBV) depends on the specific recognition of an RNA signal (the packaging signal, epsilon) on the pregenomic RNA (pgRNA) by the viral reverse transcriptase (RT). RT-epsilon interaction in the duck hepatitis B virus (DHBV) was recently shown to require the molecular chaperone complex, the heat shock protein 90...

BACKGROUND The apolipoprotein E (APOE) epsilon 4 allele is a marker of adverse outcome following head injury and intracerebral hemorrhage. Transgenic animal data in a focal cerebral ischemia model suggest that the epsilon 4 allele increases infarct size and functional impairment. OBJECTIVE To determine if APOE genotype is associated with functional recovery from ischemic stroke. DESIGN Pros...

In 2005, Exoo posed the following question. Fix $\epsilon$ with $0\leq\epsilon<1$. Let $G_\epsilon$ be graph whose vertex set is Euclidean plane, where two vertices are adjacent iff distance between them lies in closed interval $[1-\epsilon,1+\epsilon]$. What chromatic number $\chi(G_\epsilon)$ of this graph? The case $\epsilon=0$ precisely classical ``chromatic plane'' problem. a 2018 p...

PURPOSE To investigate the concentrations of Fc epsilon receptor I (Fc epsilon RI)-bindable immunoglobulin E (IgE) in the tear fluid and the proportion of IgE-saturated cells among Fc epsilon RI-positive cells in giant papillae from vernal keratoconjunctivitis (VKC) patients. METHODS The tear fluids and giant papillae were obtained from 8 VKC patients with their informed consent. To detect th...

By defining functional defects in a congenital myasthenic syndrome (CMS), we show that two mutant residues, located in a binding site region of the acetylcholine receptor (AChR) epsilon subunit, exert opposite effects on ACh binding and suppress channel gating. Single channel kinetic analysis reveals that the first mutation, epsilon N182Y, increases ACh affinity for receptors in the resting clo...