The pre-mRNA processing strategy of the B19 virus is unique among parvoviruses. B19 virus-generated pre-mRNAs are transcribed from a single promoter and are extensively processed by alternative splicing and alternative polyadenylation to generate 12 transcripts. Blockage of the production of full-length B19 virus transcripts at the internal polyadenylation site [(pA)p] was previously reported t...

The polymerase chain reaction (PCR) was investigated for detecting human parvovirus B19 (B19) DNA in sera. Three pairs of oligonucleotides were evaluated as primers. The best oligonucleotide pair spanned 699 nucleotides, including the region common to VP1 and VP2. After PCR amplification of B19 DNA in serum, a 699-nucleotide DNA fragment was detected on agarose gels. This DNA fragment was B19 D...

background and objectives: trans-placental transmission of parvovirus b19 during pregnancy can causes adverse outcomes. regarding its importance in prenatal care, we decided to study prevalence of parvovirus b19 infection among pregnant woman in ardabil, iran. materials and methods: in a community based study with a cluster sampling, 350 pregnant women that attended in health care centers in ar...

background: the etiology of the behçet disease (bd) has remained obscured. there have been studies to show the association of bd to infections like herpes simplex, hepatitis, and parvovirus b19 however, the findings are rather controversial. materials and methods: we selected 55 patients with the best matched symptoms of bd and measured the loads of b19 dna in their plasma by quantitative real ...

S. H. Chang, S. H. Hsiao, National I-Lan University, Taiwan Cold-rolled and annealed Ti50Ni40Cu10 shape memory alloy possesses a major (110)[001] texture along the rolling direction and a minor {111} γ-fiber texture along the normal direction. The damping capacity of the B2→B19 and B19→B2 martensitic transformation internal friction peaks for the Ti50Ni40Cu10 shape memory alloy was more pr...

Parvovirus B19 (B19) infection can occur during acute lymphoblastic leukemia and persistent viral infection can occur despite intravenous immunoglobulin administration. Here, evidence is presented that resolution of persistent B19 infection in an acute lymphoblastic leukemia patient may be associated with the simultaneous strengthening of antigen-specific B cell memory against the B19 capsid pr...

BACKGROUND Due to the tropism of human parvovirus B19 to erythroid progenitor cells, infection in patients with an underlying hemolytic disorder such as beta-thalassemia major leads to suppression of erythrocyte formation, referred to as transient aplasia crisis (TAC), which may be life-threatening. We investigated the prevalence of parvovirus B19 among patients with beta thalassemia major atte...

Parvovirus B19 has been linked with various clinical syndromes including neurological manifestations. However, its role in the latter remains not completely understood. Although the last 10 years witnessed a surge of case reports on B19-associated neurological aspects, the literature data remains scattered and heterogeneous, and epidemiological information on the incidence of B19-associated neu...

Human parvovirus (HPV) B19 causes significant morbidity and mortality in children with sickle cell disease (SCD), but little data are published about the epidemiology of HPV B19 infection and its associated complications in this patient population. In this study, prevalence and incidence rates of HPV B19 were determined in 633 patients with SCD followed at The Children's Hospital of Philadelphi...

human parvovirus b19 is a very common viral infection especially in school-aged children. the infection during pregnancy can affect the fetus due to lack of mother's immunity. although, there is still no evidence of fetal teratogenic effects with parvovirus b19, but non-immune fetal hydrops and abortion may be caused by vertical transmission of the virus during pregnancy. this study was aimed t...