Pterostilbene is an effective chemopreventive agent against multiple types of cancer cells. A novel pterostilbene derivative, ANK-199, was designed and synthesized by our group. Its antitumor activity and mechanism in cisplatin-resistant CAR human oral cancer cells were investigated in this study. Our results show that ANK-199 has an extremely low toxicity in normal oral cell lines. The formati...

Angiotensin-converting enzyme (ACE) inhibitory activity was evaluated for the low-molecular-weight fraction (<3 kDa) obtained from milk fermentation by Bifidobacterium longum KACC91563. The ACE inhibitory activity in this fraction was 62.3%. The peptides generated from the <3 kDa fraction were identified by liquid chromatography-electrospray ionization quantitative time-of-flight mass spectrome...

In this paper we propose a methodology for developing representation formalisms for mathematical knowledge bases. We propose to equip knowledge bases with a hierarchy of logical systems that are linked by logic morphisms. These mappings relativize formulae and proofs and thus support translation of the knowledge to the various formats currently in use in automated deduction. On the other hand t...

The construction of stiiy accurate and B-stable multi-implicit Runge-Kutta methods for parallel implementation is discussed. A fth and a seventh order method is constructed and a promising numerical comparison with the eecient Radau5 code of E. Hairer and G. Wanner is conducted.

با رشد سریع فناوری اطلاعات، تولیدکنندگان که در گذشته فقط به‌صورت سنتی و از طریق خرده‌فروشان محصولات خود را عرضه می‌کردند، می‌توانند مستقیم آنلاین نیز کنند. این پژوهش، یک زنجیره تأمین دو­کاناله شامل تولیدکننده خرده‌فروش نظر گرفته است آن می‌تواند دو کانال به فروش برساند. فرض می‌­شود محصول روش حمل درنتیجه زمان تحویل متفاوت ‌می‌کند قاعدتاً روی تقاضای یکدیگر تأثیر می‌گذارد. موردنظر ابتدا حالت غیرمتمر...

BCR-ABL1-specific tyrosine kinase inhibitors prolong the life of patients with chronic myeloid leukemia (CML) but cannot completely eradicate CML progenitors. The BH3 mimetic, ABT-263, targets prosurvival BCL2 family members, and has activity against CML progenitors. However, the inhibitory effect of ABT-263 on BCL-XL, which mediates platelet survival, produces dose-limiting thrombocytopenia. A...