Receptor activator of nuclear factor-κΒ ligand (RANKL) is necessary and sufficient to promote osteoclastogenesis a key pathogenic factor in osteoporosis. Failure periosteal apposition compensate for bone loss due endosteal resorption further contributes fragility. Whether these two processes are biologically related, however, remains unknown. Using high-resolution peripheral quantitative comput...

Introduction Pycnodysostosis (PDO) is a rare autosomal recessive lysosomal storage disease of the bone caused by a mutation in a gene mapped to chromosome 1q21 that codes for the enzyme cathepsin K (CTSK). Pycnodysostosis (Greek: pycnos = dense; dys = defective; osteon = bone) was first coined in 1962 by Maroteaux and Lamy [1], although the first case fitting the description may have been repor...

Biologically active metal ions in low doses have the potential to accelerate bone defect healing. For successful remodelling the interaction of bone graft materials with both bone-forming osteoblasts and bone resorbing osteoclasts is crucial. In the present study brushite forming calcium phosphate cements (CPC) were doped with Co2+, Cu2+ and Cr3+ and the influence of these materials on osteocla...

Periodontitis is characterized by chronic inflammation and osteoclast-mediated bone loss regulated by the receptor activator of nuclear factor-κB (RANK), RANK ligand (RANKL) and osteoprotegerin (OPG). The aim of this study was to investigate the effect of aminothiazoles targeting prostaglandin E synthase-1 (mPGES-1) on RANKL- and lipopolysaccharide (LPS)-mediated osteoclastogenesis and prostagl...

BACKGROUND Cancer genome and transcriptome analyses advanced our understanding of cancer biology. We performed transcriptome analysis of all known genes of peptidases also called proteases and their endogenous inhibitors in glioblastoma multiforme (GBM), which is one of the most aggressive and deadly types of brain cancers, where unbalanced proteolysis is associated with tumor progression. ME...