نتایج جستجو برای: ژن fcgr2a
تعداد نتایج: 15897 فیلتر نتایج به سال:
Antibody-dependent cellular cytotoxicity (ADCC) is a major mechanism of action of therapeutic monoclonal antibodies (mAbs) such as cetuximab, rituximab and trastuzumab. Fc gamma receptors (FcgR) on human white blood cells are an integral part of the ADCC pathway. Differential response to therapeutic mAbs has been reported to correlate with specific polymorphisms in two of these genes: FCGR2A (H...
Anti-glucose-6-phosphate isomerase (GPI) antibodies are known to be arthritogenic autoantibodies in K/BxN mice, although some groups have reported that few healthy humans retain these antibodies. The expression of Fcgamma receptors (FcgammaRs) is genetically regulated and has strong implications for the development of experimental arthritis. The interaction between immune complexes and FcgammaR...
The article presents a systematic review of publications devoted to the study genetic markers severe pneumonia. aim was compile list that contribute course pneumonia on basis published data. In current study, we searched for and analyzed articles between January 2000 April 2021. Following search subsequent selection articles, 10 compiled, which demonstrated clear association certain gene varian...
Janne B Kjersem ([email protected]) Eva Skovlund ([email protected]) Tone Ikdahl ([email protected]) Tormod Guren ([email protected]) Christian Kersten ([email protected]) Astrid M Dalsgaard ([email protected]) Mette K Yilmaz ([email protected]) Tone Fokstuen ([email protected]) Kjell M Tveit ([email protected]) Elin H Kure (Elin.Kure@...
Profound disruption of immune function is an established risk factor for non-Hodgkin lymphoma. We report here a large-scale evaluation of common genetic variants in immune genes and their role in lymphoma. We genotyped 57 single nucleotide polymorphisms (SNP) from 36 candidate immune genes in 1,172 non-Hodgkin lymphoma cases and 982 population-based controls from a US multicenter study. We calc...
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