Allen, M. J., Boyland, E., Dukes, C. E., Homing, E. S. & Watson, J. G. (1957). Brit. J. Cancer, 11, 212. Azzone, G. F. & Ernster, L. (1961). J. biol. Chem. 236, 1501. Barnabei, O., Papa, S. & Quagliariello, E. (1963). Arch. Biochem. Biophy8. 101, 573. Borst, P. & Slater, E. C. (1961). Biochim. biophy8. Acta, 48, 372. Boyland, E. (1958). Brit. med. Bull. 14, 153. Boyland, E. & Williams, D. C. (1...

PAPA syndrome (pyogenic sterile arthritis, pyoderma gangrenosum, and acne, OMIM #604416) and familial recurrent arthritis (FRA) are rare inherited disorders of early onset, primarily affecting skin and joint tissues. Recurring inflammatory episodes lead to accumulation of sterile, pyogenic, neutrophil-rich material within the affected joints, ultimately resulting in significant destruction. We ...

Bacillus subtilis can attain cellular protection against the detrimental effects of high osmolarity through osmotically induced de novo synthesis and uptake of the compatible solute l-proline. We have now found that B. subtilis can also exploit exogenously provided proline-containing peptides of various lengths and compositions as osmoprotectants. Osmoprotection by these types of peptides is ge...

HS: hidradenitis suppurativa IL: interleukin PAPA: pyoderma gangrenosum with pyogenic sterile arthritis and cystic acne PAPASH: pyoderma gangrenosum with pyogenic sterile arthritis, acne, and hidradenitis suppurativa PASH: pyoderma gangrenosum with cystic acne and hidradenitis suppurativa PG: pyoderma gangrenosum INTRODUCTION Pyoderma gangrenosum (PG) is a neutrophilic dermatitis, the prevalenc...

Whereas previous studies suggest that tumor necrosis factor-alpha (TNF-alpha) induces cardiac contraction-relaxation deficits, the mechanisms remain unclear. Our recent studies have implicated cardiac-derived nitric oxide (NO). This study examined the detrimental and protective effects of NO donors S-nitroso-N-acetyl-penicillamine (SNAP) or (Z)-1- [N-(3-ammonio-propyl)-N-(n-propyl)amino]diazen-...

Pyrin, the familial Mediterranean fever protein, is found in association with the cytoskeleton in myeloid/monocytic cells and modulates IL-1beta processing, NF-kappaB activation, and apoptosis. These effects are mediated in part through cognate interactions with the adaptor protein ASC, which shares an N-terminal motif with pyrin. We sought additional upstream regulators of inflammation by usin...

1. Jonsson CB, Figueiredo LT, Vapalahti O. A global perspective on hantavirus ecology, epidemiology, and disease. Clin Microbiol Rev. 2010;23:412–41. DOI: 10.1128/ CMR.00062-09 2. Aitichou M, Saleh SS, McElroy AK, Schmaljohn C, Ibrahim MS. Identifi cation of Dobrava, Hantaan, Seoul, and Puumala viruses by one-step real-time RT-PCR. J Virol Methods. 2005;124:21–6. DOI: 10.1016/j.jviromet.2004.10...