BACKGROUND The assessment of target organ damage is important in the evaluation of a hypertensive patient as it provides information on the severity of the hypertension and the cardiovascular risk assessment. The aim of our study was to determine the usefulness of the chest radiograph in the assessment of target organ damage in hypertensive patients. METHODS Unselected patients attending an a...

Seizures are a well known consequence of human cocaine abuse, and in rodent models, sensitivity to cocaine seizures has been shown to be strongly influenced by genotype. For example, several studies have reported significant differences between the C57BL/6 (B6) and DBA/2 (D2) inbred mouse strains in their sensitivity to cocaine-induced seizures. This prompted our use of the BXD recombinant inbr...

Linkage of body mass index (BMI) to a broad region of chromosome 7q22-35 has been reported in multiple studies. We previously published a multipoint LOD score of 4.9 at D7S1804 for BMI from the National Heart, Lung, and Blood Institute Family Heart Study. Leptin (LEP), the human homolog of the mouse obesity (ob) gene, is positioned near the linkage peak and is the most prominent candidate gene ...

The incidence of mold infections in patients with hematologic malignancies continues to increase despite the widespread use of air filtration systems, suggesting the presence of other hospital sources for these molds. Water sources are known to harbor pathogenic molds. We examined samples from water, water surfaces, air, and other environment sources from a bone marrow transplantation unit with...

OBJECTIVE To establish simultaneous pre- and postductal oxygen saturation nomograms in asymptomatic newborns when screening for critical congenital heart disease (CCHD) at ∼24 hours after birth. METHODS Asymptomatic term and late preterm newborns admitted to the newborn nursery were screened with simultaneous pre- and postductal oxygen saturation measurements at ∼24 hours after birth. The scr...

Keyboard entry or correction of radiology reports by radiologists and transcriptionists remains necessary in many settings despite advances in computerized speech recognition. A report entry system that implements an automated phrase completion feature based on language modeling was developed and tested. The special text editor uses context to predict the full word or phrase being typed, updati...

Keyboard entry or correction of radiology reports by radiologists and transcriptionists remains necessary in many settings despite advances in computerized speech recognition. A report entry system that implements an automated phrase completion feature based on language modeling was developed and tested. The special text editor uses context to predict the full word or phrase being typed, updati...

This paper explores through simulation an abstract model of distributed matchmaking within multi-agent systems. We show that under certain conditions agents can find matches for cooperative tasks without the help of a predefined organization or central facilitator. We achieve this by having each agent search for partners among a small changing set of neighbors. We work with a system where agent...

BACKGROUND AND PURPOSE The possibility of using MR imaging as a sensitive marker of the structural changes in Parkinson's disease has been a long-sought goal. We describe a new method for imaging and quantifying the morphologic changes of the substantia nigra in Parkinson's disease and compare radiologic findings with clinical evaluation. METHODS Using a combination of two MR imaging inversio...