NOV-002 is a novel glutathione disulfide mimetic that when administered in combination with standard chemotherapeutic regimens has resulted in increased efficacy (survival, tumor response) and improved tolerance to chemotherapy (e.g., hematologic recovery) in advanced non–small cell lung cancer patients. We show that NOV-002, which is not cytotoxic as a single agent, generated timeand concentra...

V.T. Nguyen College of Natural Sciences, Vietnam National University, Hanoi, Vietnam B.D. Nguyen · H.T. Nguyen Molecular Genetics and Plant Genomics Laboratory, Texas Tech University, Lubbock, TX 79409, USA S. Sarkarung International Rice Research Institute (IRRI), MCPO Box 3127, Mataki City, Philippines C. Martinez International Center for Tropical Agriculture (CIAT), Apartado Aereo 6713, Cali...

Natural killer (NK) cell responses in primates are regulated in part through interactions between two highly polymorphic molecules, the killer-cell immunoglobulin-like receptors (KIRs) on NK cells and their major histocompatibility complex (MHC) class I ligands on target cells. We previously reported that the binding of a common MHC class I molecule in the rhesus macaque, Mamu-A1*002, to the in...

Introduction: policosanol, a mixture of higher aliphatic alcohols purified from sugar cane wax, is used to treat hypercholesterolemia. D-002 (Abexol), a mixture of higher aliphatic alcohols from beeswax, is an antioxidant supplement with gastroprotective effects. Then, concomitant intake of D-002 and policosanol may occur in routine practice, so potential pharmacological interactions between th...

Nonsteroidal antiinflammatory drugs include the traditional drugs and more selective COX-2 inhibitors. Traditional nonsteroidal antiinflammatory drug use is hampered by their gastrotoxicity, while COX-2-inhibitors increase the cardiovascular risk. The search of safer substances for managing inflammatory conditions is updated, a challenge wherein dual COX/5-LOX inhibitors have a place. This revi...

BACKGROUND: The treatment of Osteoarthritis (OA) is addressed to pain alleviation and functional status improvement. Non-steroidal anti-inflammatory drug (NSAIDs), widely prescribed for OA, have been show to produce gastrointestinal (non selective) and cardiovascular (ciclooxygenase– 2 inhibitors) adverse effects. Then, the search for new substances is justified. D-002 is a mixture of higher al...

D-002, a mixture of six higher aliphatic alcohols purified from beeswax, has been shown to produce anti-inflammatory effects in experimental models, devoid of gastrotoxic or hepatotoxic effects. Some studies have demonstrated that D-002 exerts analgesic effects, but just related to its anti-inflammatory action. The objective of this study was to compare the effects of D-002, naproxen, aspirin a...

Abstract Light curves feature many kinds of variability, including instrumental systematics, intrinsic stellar variability such as pulsations, and flux changes caused by transiting exoplanets or eclipsing binary stars. Detrending is a key pre-planet-search data processing step that aims to remove not due transits. This release note describes improvements the Quick-Look Pipeline's detrending alg...