نتایج جستجو برای: 003 lmj
تعداد نتایج: 7141 فیلتر نتایج به سال:
Both policosanol and D-003 are mixtures of higher aliphatic alcohols and acids, respectively, purified from sugarcane wax, whose main components are octacosanol and octacosanoic acid (an active metabolite of octacosanol), respectively. Both substances share some, not all, pharmacological effects, like cholesterol-lowering, antiplatelet and antioxidant effects. The mechanisms whereby they exhibi...
PURPOSE Cancer cells are highly dependent on folate metabolism, making them susceptible to drugs that inhibit folate receptor activities. Targeting overexpressed folate receptor alpha (FRα) in cancer cells offers a therapeutic opportunity. We investigated the functional mechanisms of MORAB-003 (farletuzumab), a humanized mAb against FRα, in ovarian cancer models. EXPERIMENTAL DESIGN We first ...
Neurokinin A (NKA) causes bronchoconstriction in asthmatic patients. In vitro both NK1 and NK2 receptors can mediate airway contraction. Moreover in guinea pigs, NK3 receptors facilitate cholinergic neurotransmission. Dual tachykinin NK1/NK2 receptor antagonism results in prevention of NKA-induced bronchoconstriction. We have now examined the effect of a single dose of the triple tachykinin rec...
BACKGROUND/AIMS Increased osteoclast activity is a pivotal finding in osteoporosis. This increase is mediated via the mevalonate-to-cholesterol pathway, which is involved in producing the intermediates required for osteoclast activity. D-003, a mixture of high molecular weight sugarcane wax acids, has been shown to inhibit cholesterol synthesis prior to mevalonate production, resulting in a red...
Abstract A 2 mm gas gap Resistive Plate Chamber with bakelite plates has been operated in avalanche mode under a 137Cs source irradiation. We report on measurements of the efficiency in cosmic rays detection and of the charge developed in the gap, performed for two different gas mixtures: the first containing a high percentage of environmental friendly ”freon” C2H2F4; the second one having a hi...
Introduction The PFAPA syndrome is a non-mendelian autoinflammatory disease of unknown aetiology characterized by Periodic Fever, Aphthous stomatitis, Pharyngitis, and cervical Adenitis. In typical cases, attacks begin before the age of five and occur every 2-8 weeks, often with striking periodicity. We have previously profiled the blood cells and serum cytokine levels in a cohort study of pati...
Back cover image: The crystal plane exposure is of great significance to the structural stability layered cathodes. In article number 10.1002/cey2.298, Qiu and co-workers deciphered degradation discrepancy Ni-rich cathode with a diverse proportion [003] crystallographic textures, revealing structure-activity relationship between face oxygen release stability. Although textures was conducive Li+...
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