The cooling crystallization of carbapenem CS-023 was performed at 25 °C in an aqueous solution. Tetrahydrate crystals (form H) were obtained. Hydrate are promising drugs, but there has been problems manufacturing such crystals. During crystallization, a dissolution process high temperature 70 utilized. main problem that the degradation rate high, as expressed half-life period 2.97 h. Poor solve...

Results Ex vivo cytokine profile The levels of pro-inflammatory cytokines IL-6 and TNF-a were higher in unstimulated and LPS stimulated PBMC supernatants of FMF patients in crises compared to the control group. Concentrations were comparable between FMF patients during and between crises. There was no difference in spontaneous IL1-b and IL-1 a release by PBMCs of FMF patients and controls. Howe...

Introduction Tight association of the pro-inflammatory events with the pathogenesis of a majority of serious human diseases (neoplasia, neurodegenetarions, cardiovascular and others) in addition to inflammatory and autoinflammatory diseases is firmly documented. S100A4 is a metastasis-promoting gene whose expression has been found implicated in chronic inflammation. Earlier we have shown an imm...

Introduction A patient with familial Mediterranean fever (FMF) in addition to undiagnosed Anklosing Spondylitis (AS) and also having cutaneous leukocytoclastic vasculitis (LV) is presented. Coexistence of FMF with inflammatory disorders including spondyloarthritis and various systemic vasculitides has been reported before. Meanwhile this is the first reported case of FMF, AS, and LV present tog...

Dekoko (Pisum sativum var. abyssinicum) is one of the most important food legumes grown in south Tigray and north Wollo, northern Ethiopia. It is one among the most important food legumes in terms of protein content. It grows mixed and alone with many cereal crops growing in north Ethiopia. This study was conducted in 2015/2016with the objective of selecting adaptable and relatively high yieldi...