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Purpose Intratumoral immune activation can induce systemic immunity and anti-tumor activity. Imiquimod is a creamformulated, TLR-7 agonist that is FDA-approved for the treatment of non-melanoma skin cancers, but has limited activity against melanoma. In the current study, we studied the anti-tumor activity and mechanism of action of a novel injectable TLR 7/8 dual agonist, 3M-052, which remains...

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Walid Hetaba,1,* Peter Blaha,2 Fabien Tran,2 and Peter Schattschneider1,3 1Institute of Solid State Physics, Vienna University of Technology, Wiedner Hauptstraße 8-10/138, A-1040 Vienna, Austria 2Institute of Materials Chemistry, Vienna University of Technology, Getreidemarkt 9/165-TC, A-1060 Vienna, Austria 3University Service Center for Transmission Electron Microscopy, Vienna University of T...

Nam Deuk Kim*, Eun Ok Im, Yung Hyun Choi and Young Hyun Yoo Department of Pharmacy, Pusan National University, Pusan Cancer Research Center, Pusan 609-735 Department of Biochemistry, College of Oriental Medicine, Dong-Eui University, and Research Center for Oriental Medicine, Pusan 614-052, Department of Anatomy and Cell Biology, Dong-A University College of Medicine and Institute of Medical Sc...

TOMOHIDE YASUNAGA1, ZAYAR SOE2, SHINE SHANE NAING2 & ANDRZEJ WOLSKI3 1Research Associate, Division of Invertebrate Zoology, American Museum of Natural History, New York, c/o JICA (Japan International Cooperation Agency) Myanmar Office, #701 Sakura Tower No. 339, Bogyoke Aung San Road, Kyauktada Township, Yangon. E-mail: [email protected] 2Fluit Fly Laboratory, Plant Protection Division (PPD), ...

We have been examining the abundance distributions in metal-poor Galactic halo stars trying to identify, and understand, the signatures of the slowand rapid-neutron capture processes (i.e., the sand the r-process). Detailed studies have been made of the stars CS 22892–052 [1, 2] and HD 115444 [3]. In our latest work we have added to this list the metal-poor ([Fe/H] = –2.0) halo star BD +17◦3248...

In order to intelligently select the correct high speed op amp for a given application, an understanding of the various op amp topologies as well as the tradeoffs between them is required. The two most widely used topologies are voltage feedback (VFB) and current feedback (CFB). An overview of these topologies has been presented in previous tutorials (MT-050, MT051, MT-052), but the following d...