Cortical GABAergic abnormalities have been widely documented in neuropsychiatric disorders with prenatal infectious etiologies, including schizophrenia and autism. However, the extent to which prenatal exposure to immune challenge can induce long-term alterations in GABAergic gene transcription remains largely elusive. Thus, we used a well established mouse model of prenatal immune activation i...

We report results of analysis of the ASCA observation of the Low Mass X-ray Binary dipping source XB 1916-053 made on 1993, May 2nd, during which dipping was very deep such that in the deepest parts of dips, the X-ray intensity in the band 0.5-12.0 keV fell to zero, demonstrating that all emission components were completely removed. The best-fit orbital period of the binary system determined fr...

A set of full-length cDNA clones of the satellite RNA of grapevine fanleaf nepovirus isolate F13 (GFLV-F13) was constructed with a variable number of additional, non-viral nucleotides at the 5' and 3' ends. The biological activity of the RNAs transcribed from these constructs was tested in Chenopodium quinoa protoplasts using a helper virus. When inoculated with arabis mosaic virus S (ArMV-S) R...

We report the discovery of a highly coherent oscillation in a type-I X-ray burst observed from 4U 1916−053 by the Rossi X-ray Timing Explorer (RXTE ). The oscillation was most strongly detected ≈ 1 s after the burst onset at a frequency of 269.3 Hz, and it increased in frequency over the following 4 seconds of the burst decay to a maximum of ≃272 Hz. The total measured drift of 3.58 ± 0.41 Hz (...

Background: Impaired γ-aminobutyric acid (GABA) signaling may contribute to the emergence of cognitive deficits and subcortical dopaminergic hyperactivity in patients with schizophrenia and related psychotic disorders. Against this background, it has been proposed that pharmacological interventions targeting GABAergic dysfunctions may prove useful in correcting such cognitive impairments and do...

The ultra-compact Low Mass X-ray Binary (LMXB) X1916-053, composed of a neutron star and a semi-degenerated white dwarf, exhibits periodic X-ray dips with variable width and depth. We have developed new methods to parameterize the dip to systematically study its variations. This helps to further understand binary and accretion disk behaviors. The RXTE 1998 observations clearly show a 4.87d peri...

BACKGROUND Impaired γ-aminobutyric acid (GABA) signaling may contribute to the emergence of cognitive deficits and subcortical dopaminergic hyperactivity in patients with schizophrenia and related psychotic disorders. Against this background, it has been proposed that pharmacological interventions targeting GABAergic dysfunctions may prove useful in correcting such cognitive impairments and dop...