Abstract Sulfoglycolipid, SQAP, is a radiosensitizing agent that makes tumor cells more sensitive to radiation therapy. A previous study revealed SQAP induced the degradation of hypoxia-inducible factor-1α (HIF-1α) and inhibited angiogenesis in hepatoma model mouse. Herein, we examined biological activities against hepatocarcinoma under low oxygen conditions. Cell growth inhibition hypoxic cond...

In Hashimoto’s thyroiditis (HT), oxidative stress (OS) is driven by Th1 cytokines’ response interfering with the normal function of thyrocytes. OS results from an imbalance between excessive production reactive oxygen species (ROS) and a lowering antioxidant production. Moreover, has been shown to inhibit Sirtuin 1 (SIRT1), which able prevent hypoxia-inducible factor (HIF)-1α stabilization. The...

Recent studies have provided novel insights of co-development the neural and vascular elements retina. Knowledge these relationships are crucial to understand impact therapeutic measures in Retinopathy Prematurity (ROP). ROP is imposed by oxygen upon immature retinal blood vessels cells causing delayed development regression. However, hyperoxia on developing neurons less understood because some...

Cellular adaptive mechanisms are crucial for tumorigenesis and a common feature in solid tumor progression. Hypoxia-inducible factor-1α (HIF-1α) facilitates the biological response to hypoxia, advancing angiogenesis and metastatic potential of the tumor. The peroxisome proliferator-activated receptor γ coactivators 1α (PGC-1α) enhances mitochondrial biogenesis, favored by migratory/invasive can...

The transcriptional coactivator peroxisome proliferator-activated receptor γ coactivator (PGC)-1α and its splice variant N terminal (NT)-PGC-1α regulate adaptive thermogenesis by transcriptional induction of thermogenic and mitochondrial genes involved in energy metabolism. We previously reported that full-length PGC-1α (FL-PGC-1α) is dispensable for cold-induced nonshivering thermogenesis in F...

BACKGROUND Hypoxia-inducible factor 1α (HIF-1α) is an important regulator of immune and inflammatory responses. We hypothesized that nasal allergic inflammation is attenuated by HIF-1α inhibition and strengthened by HIF-1α stabilization. OBJECTIVE To elucidate the role of HIF-1α in a murine model of allergic rhinitis (AR). METHODS Mice were pretreated with the HIF-1α inhibitor 2-methoxyestr...

introduction: hematopoietic stem cells are always in a quiescence state. since they need retroviral transduction to infect dividing cells, they are resistant to retrovirus transduction. they need to be pre-stimulated by a cytokine cocktail. for proliferation without maturation, we suggest mip-1α as a novel factor. material and methods: retroviral vector produced by pg13/ln c8 cells titter on he...