Relatively little work has been done with pyridoxine displacers. Ott (1) found 2,4-dimethyl-3-hydroxy-5-hydroxymethylpyridoxine (desoxypyridoxine) to be a very potent inhibitor of pyridoxine in the metabolism of the chick. 2 molecules of inhibitor were sufficient to offset the vitamin activity of 1 molecule of pyridoxine. In the course of an investigation of antimalarials, McCasland et al. (2) ...

Condensation and cyclization of 5-hydroxy- 1,2,4- thiadiazol-2-yl hydrazine 1 with pyruvic acid, phenacyl bromide, propargyl bromide and ally1 bromide afforded compounds 2,5,7 3, 4 ,6 and 8 respectively, Reaction of 1 with epichforohydrine afforded 4-hydroxy-N-[5-hydroxy- 1 ,3,4-thiadiazoly1] pyrazolidine 9