For example, on input a1, a2, a3, a4, a5 where a1 = 3, a2 = 4, a3 = 4, a4 = 5, a5 = 7, a possible solution is to take S1 = {1, 4} and S2 = {2, 3}, bacause a1 + a4 = a2 + a3 = 8. On the other hand, on input the sequence 2, 3, 4, there is no possible solution. Devise a dynamic programming strategy to decide whether such sets S1 and S2 exists. The solution should run in time polynomial in n and M ...

We consider a model based on A4 ⋉ (Ze ×Zμ ×Zτ ) flavor symmetry for TriBimaximal lepton mixing with two scalar A4-triplets whose vacuum expectation values have the same alignment. Neutrino masses are generated through effective dimension five Weinberg operators. Charged leptons mass hierarchies are generated with an additional Froggatt-Nielsen U(1)F flavor symmetry under which right-handed lept...

Phenothiazines (PTZs) have been used for the antipsychotic drugs for centuries. However, some of these PTZs have been reported to exhibit antitumor effects by targeting various signaling pathways in vitro and in vivo. Thus, this study was aimed at exploiting trifluoperazine, one of PTZs, to develop potent antitumor agents. This effort culminated in A4 [10-(3-(piperazin-1-yl)propyl)-2-(trifluoro...

Clostridium botulinum subtype A4 neurotoxin (BoNT/A4) is naturally expressed in the dual-toxin-producing C. botulinum strain 657Ba at 100× lower titers than BoNT/B. In this study, we describe purification of recombinant BoNT/A4 (rBoNT/A4) expressed in a nonsporulating and nontoxigenic C. botulinum expression host strain. The rBoNT/A4 copurified with nontoxic toxin complex components provided in...

Rabphilin is a synaptic vesicle-associated protein proposed to play a role in regulating neurotransmitter release. Here we report the isolation and identification of a novel protein complex containing rabphilin, annexin A4 and synaptotagmin 1. We show that the rabphilin C2B domain interacts directly with the N-terminus of annexin A4 and mediates the co-complexing of these two proteins in PC12 c...

Plexins belonging to the plexin-A subfamily form complexes with neuropilins and propagate signals of class 3 semaphorins into neurons, even though they do not directly bind the semaphorins. In this study, we identified a new member of the plexin-A subfamily in the mice, plexin-A4, and showed that it was expressed in the developing nervous system with a pattern different to that of other members...

We present a see-saw A4 model for Tri-Bimaximal mixing which is based on a very economical flavour symmetry and field content and still possesses all the good features of A4 models. In particular the charged lepton mass hierarchies are determined by the A4 × Z4 flavour symmetry itself without invoking a Froggatt-Nielsen U(1) symmetry. Tri-Bimaximal mixing is exact in leading order while all the...

Plexins and semaphorins are ligand-receptor pairs that serve as guidance molecules in the nervous system and play some roles in immunity. Plexins are similar to the Toll-like receptors (TLRs) in their evolutionary conservation from flies to mammals. By studying plexin-A4-deficient (Plxna4(-/-)) innate immune cells, in this study we show a novel influence of plexin-A4 on TLR signaling. Plxna4(-/...

The lipoxins are the first proresolution mediators to be recognized and described as the endogenous "braking signals" for inflammation. We evaluated the anti-inflammatory and proresolution bioactions of lipoxin A4 in our lipopolysaccharide (LPS-)induced lung injury model. We demonstrated that lipoxin A4 significantly improved histology of rat lungs and inhibited IL-6 and TNF- α in LPS-induced l...