The dichloromethane fraction of Hedranthera barteri (DMHBR), a common medicinal plant, was investigated in animal models of depression and anxiety in mice. Graded doses (25-200mg/kg p.o. bw) of DMHBR reduced the immobility time with significant effects produced by 50mg/kg (43.7%), 100mg/kg (45.6%) and 200mg/kg (31.5%) in the tail suspension test (TST) and by 100mg/kg (66.3%) in forced swimming ...

PURPOSE To evaluate and to compare the possible toxic effects of oxcarbazepine (OXC) and valproic acid (VPA) on retinal ganglion cells (RGCs) in rat. METHODS Forty female Wistar rats (21-24 days old and weighted between 44.6 and 57.3g) were divided equally into 4 experimental groups which were applied tap water (group 1), 300mg/(kgday) VPA (group 2), 100mg/(kgday) OXC (group 3), and both VPA ...

mechanism behind this apparent thalidomide-induced hyperkalaemia remains unclear. Therefore, the authors recommend caution when thalidomide is used in patients with moderate to severe renal failure (serum creatinine >300mmol/l) or in patients on dialysis. To go a step further, we think that thalidomide should in all cases be started at a dosage that should not exceed 100mg/day. It is also impor...

Background: The frequent use of herbal preparations for treatment of infections and diseases have led to the need to investigate possible side effects that could be associated with these plants. Objective of study: This study was designed to investigate the effects of aqueous leaf extracts of Albizzia lebbeck on the histology of the male and female reproductive organs of alloxan induced diabeti...

The hypoglycemic effect of cinnamon oil (CO) in a type 2 diabetic animal model (KK-A(y) mice) was studied. The main component of CO was cinnamaldehyde, and other nineteen components were also determined. CO was administrated at doses of 25, 50 and 100mg/kg for 35 days. It was found that fasting blood glucose concentration was significantly decreased (P<0.05) with the 100mg/kg group (P<0.01) the...

Removal of bacterial biofilm from the root canal system is essential for the management of endodontic disease. Here we evaluated the antibacterial effect of N-acetylcysteine (NAC), a potent antioxidant and mucolytic agent, against mature multispecies endodontic biofilms consisting of Actinomyces naeslundii, Lactobacillus salivarius, Streptococcus mutans and Enterococcus faecalis on sterile huma...

Methods Data were pooled from 3 DRV/RTV PK studies. In total 51 HIV-infected patients (7 female) stable on DRV/RTV (800/100mg or 900/100mg once daily; n=32 and 19, respectively) were included. Median age, weight, BMI, RTV area under the curve over 24h (AUC0-24) and baseline CD4 cell count were 39yr (21-63), 74kg (57-105), 24kg/m (18-31), 4.35mg.h/L (2.27-10.99) and 500cells/ mm (227-1129), resp...

Tujuan penelitian untuk mengetahui efek antiulkus isolat fukoidan dan Sargassum polycystum terhadap tikus putih jantan. Sampel terdiri dari 45 ekor jantan dibagi 9 kelompok yaitu normal, CMC-Na, sukralfat, 25mg/kgbb, 50mg/kgbb 100mg/kgbb. Perlakuan diberi per oral selama 10 hari. Pada hari ke-10, dipuasakan 24 jam diberikan induksi etanol P.A. Kemudian dikorbankan diambil lambung dilakukan peme...

BACKGROUND Diabetes rats have been linked to reproductive dysfunction and plant medicine has been shown to be effective in its treatment. Antioxidants have distinctive effects on spermatogenesis, sperm biology and oxidative stress, and changes in anti-oxidant capacity are considered to be involved in the pathogenesis of chronic diabetes mellitus. Ginger and cinnamon are strong anti-oxidants and...

This study was conducted to determine the effects of Ficus exasparata (sand paper plant) on albino mice experimentally infected with Plasmodium berghei berghei. The were grouped into four five each. in groups A,B, and C inoculated while those group D not parasite serve as control group. Group A B treated ethanoic leaf extract 100mg/body weight/day 200mg/body respectively for six days after inoc...