The pathway involving the tumor suppressor gene TP53 can regulate tumor angiogenesis by unclear mechanisms. Here we show that p53 regulates hypoxic signaling through the transcriptional regulation of microRNA-107 (miR-107). We found that miR-107 is a microRNA expressed by human colon cancer specimens and regulated by p53. miR-107 decreases hypoxia signaling by suppressing expression of hypoxia ...

Abnormal expression of microRNA-107 (miR-107) was found in non-small cell lung cancer (NSCLC). However, little is known about its role and molecular mechanism in NSCLC progression and metastasis. Therefore, the aims of this study were to clarify the potential role of miR-107 and molecular mechanism in NSCLC progression and metastasis. Quantitative real-time polymerase chain reaction assay showe...

A Fourier–Chebyshev Petrov–Galerkin spectral method is described for high-accuracy computation of linearized dynamics for flow in an infinite circular pipe. Our code is unusual in being based on solenoidal velocity variables and in being written in MATLAB. Systematic studies are presented of the dependence of eigenvalues, transient growth factors, and other quantities on the axial and azimuthal...

In the Flipped classroom based on smart-learning, the participants studied at home in advance with materials made by their teachers. Then, in class, they searched data instantly by using smart pads, used applications for learning or as a tool, and conducted online evaluation, etc. The normal flipped learning-based education group studied at home in advance with videos made by their teachers and...

BACKGROUND The biological processes and molecular mechanisms underlying miR-107 remain unclear in gastric cancer(GC). In this study, we aimed to investigate the expression, biological functions and mechanisms of miR-107 in GC. METHODS Quantitative real-time RT-PCR was used to test miR-107 expression. MTT and colony formation assays were conducted to explore the potential function of miR-107 i...

MicroRNAs are small non-coding RNA molecules that control expression of target genes. Previous studies showed that microRNA-107 (miR-107) is overexpressed in gastric cancer tissues compared with the matched normal tissues. However, it remains largely unclear as to how miR-107 exerts its function and modulates the malignant phenotypes of gastric cancer, because our understanding of miR-107 signa...