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Previous evaluation of lymphocytes taken from patients with Wiskott-Aldrich syndrome (WAS) and other X-linked immunodeficiencies has revealed deficiencies of a lymphocyte sialoglycoprotein with a relative molecular mass of 115 kD (designated gpL-115) found in normal lymphocytes. The development of monoclonal antibodies to gpL-115 has permitted the detection of molecular heterogeneity in gpL-115...
Autism spectrum disorder (ASD) is a mental condition, present from early childhood, characterized by great difficulty in communicating and forming relationships with others and using language. In the last four decades many studies have shown that immune responses in different regions of brain play an important role in ASD pathogenicity. A conservative estimate based on the research suggests tha...
بی تردید جایگاه ریاست جمهوری از خطیرترین و مؤثرترین مناصب در جمهوری اسلامی است و لازمه ی تصدی این سمت، دارا بودن توانمندی ها و خصایص متعددی است. ازاین رو قانونگذار اساسی به منظور انعکاس اهمیت این جایگاه و مسئولیت های آن، در اصل 115 از ضرورت رجل مذهبی و سیاسی بودن رئیس جمهور سخن گفته است. نمایندگان مجلس خبرگان قانون اساسی معتقد بودند رئیس جمهور یا رأساً به اعمال ولایت می پردازد یا به نیابت و وکال...
Agronomy JournalVolume 115, Issue 3 COVER IMAGEFree Access Cover Image, Volume First published: 15 May 2023 https://doi.org/10.1002/agj2.21114AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text full-text accessPlease review our Terms and Conditions of Use check box below share version article.I have read accept the Wiley Online Lib...
VEGF receptor (VEGFR) signaling plays a key role in tumor angiogenesis. Although some VEGFR signal-targeted drugs have been approved for clinical use, their utility is limited by associated toxicities or resistance to such therapy. To overcome these limitations, we developed TAS-115, a novel VEGFR and hepatocyte growth factor receptor (MET)-targeted kinase inhibitor with an improved safety prof...
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