Many experimental studies have shown that the prion AGAAAAGA palindrome hydrophobic region (113-120) has amyloid fibril forming properties and plays an important role in prion diseases. However, due to the unstable, noncrystalline and insoluble nature of the amyloid fibril, to date structural information on AGAAAAGA region (113-120) has been very limited. This region falls just within the N-ter...

BACKGROUND Quick diagnosis of smear-negative pulmonary tuberculosis (TB) and extra-pulmonary TB are urgently needed in clinical diagnosis. Our research aims to investigate the usefulness of the interferon-γ release assay (IGRA) for the diagnosis of smear-negative pulmonary and extra-pulmonary TB. METHODS We performed TB antibody and TB-IGRA tests on 389 pulmonary TB patients (including 120 sm...

Family Planning Perspectives Through the mid-1980s, Medicaid eligibility requirements included very low income thresholds established by the individual states. Between 1987 and 1991, eligibility standards for poor and near-poor pregnant women were expanded dramatically. The 1986 Omnibus Budget and Reconciliation Act (OBRA) permitted states to extend eligibility (and receive reimbursement for se...

Ageing is accompanied by a progressive loss of skeletal muscle mass and strength, leading to the loss of functional capacity and an increased risk for developing chronic metabolic diseases such as diabetes. The age-related loss of skeletal muscle mass results from a chronic disruption in the balance between muscle protein synthesis and degradation. As basal muscle protein synthesis rates are li...

Obesity is a multifactor, chronic metabolic disease involving an excessive build-up of adipose tissue in the body. The severity of obesity is measured with the Body Mass Index (BMI). A BMI within the range of 25-29.9 kg/m indicates overweight, while a BMI exceeding 30 kg/m indicates obesity. The higher the BMI, the greater the disease risk for obesity-related comorbidities. Currently more than ...

The research, based on an interdisciplinary literature review, highlights the strategic choices, various profiles and salient factors of electronic procurement (eprocurement). The authors identify some factors which are important when adopting a strategic, rather than a tactical e-procurement perspective. The article proposes a broad framework for assessing the e-procurement performance relatio...

Rapamycin is a canonical allosteric inhibitor of the mammalian tarpet of rapamycin (mTOR) kinase with immunosuppressive and proapoptotic activities. We found that in vitro rapamycin also regulates the proteasome, which is an essential intracellular protease of the ubiquitin-proteasome pathway. Rapamycin inhibits proteinase and selected peptidase activities of the catalytic core proteasome at lo...

1The authors thank Trine Poulsen, Annette K. Nielsen, and Kasper B. Poulsen for their skilled technical assistance. The project was fi nancially supported by the Danish Council for Strategic Research (FØSU 2101-07-0111). 2Corresponding author: [email protected] ABSTRACT: Free fatty acids (FFA) are produced in the intestine by microbial fermentation. Recently, a family of G protein-coupled re...

OBJECTIVES Increasing numbers of minor surgical procedures are being performed in the community. In the UK, general practitioners (family medicine physicians) with a specialist interest (GPwSI) in surgery frequently undertake them. This shift has caused decreases in available cases for junior surgeons to gain and consolidate operative skills. This study evaluated GPwSI's case-load, procedural t...

Effects of Aerosol Inhalation by the E‐Cigarette User 100 Dose and Effects of Inhaling Aerosolized Nicotine 100 Aerosolized Nicotine and Cardiovascular Function 101 Aerosolized Nicotine and Dependence 102 Effects of Nicotine in Youth Users 104 Nicotine Exposure from Maternal Nicotine Consumption: Prenatal and Postnatal Health Outcomes 108 Summary 113 Effects of the Inhalation of Aerosol Constit...