Since its introduction into clinical practice, multimodality imaging has revolutionized diagnostic for both oncologic and non-oncologic pathologies. 18 F-fluorodeoxyglucose ( F-FDG) PET/CT which takes advantage of increased anaerobic glycolysis that occurs in tumor cells (Warburg effect) gained significant relevance the management most, if not all conditions. Because FDG is taken by normal abno...

Background: Magnetic resonance imaging (MRI) contrast agents have an important role to differentiate healthy and diseased tissues. Access and design new contrast agents for the optimal use of MRI are necessary. This study aims to evaluate iron oxide–4A nanocomposite ability to act as a magnetic resonance imaging contrast agent.Materials and Methods: Iron oxide–4A nanocomposite (F4A) was syn...

Ultrasound imaging, one of the common diagnosis techniques, is frequently used since it safe, cost-efficient technique and real-time imaging can be conducted. However, various organs tissues reflect ultrasonic waves, which leads to difficulty in small biomolecules a low spatial resolution for deep-tissue images. As such, there have been significant advances photonics optical molecular probes re...

Detecting aggregated amyloid peptides (Abeta plaques) presents targets for developing biomarkers of Alzheimer's disease (AD). Polymeric n-butyl-2-cyanoacrylate (PBCA) nanoparticles (NPs) were encapsulated with radiolabelled amyloid affinity (125)I-clioquinol (CQ, 5-chloro-7-iodo-8-hydroxyquinoline) as in vivo probes. (125)I-CQ-PBCA NPs crossed the BBB (2.3 +/- 0.9 ID/g) (P < .05) in the WT mous...

Polyamidoamine (PAMAM)-entrapped Au nanoparticles were synthesized with distinct sizes to figure out the size effect of Au-based contrast agent on CT imaging of passively targeted tissues. Au/PAMAM nanoparticles were first synthesized with narrow distribution of particles size of 22.2 ± 3.1, 54.2 ± 3.7, and 104.9 ± 4.7 nm in diameters. Size effect leads no significant difference on X-ray attenu...

introduction: data on imaging findings in pulmonary complications of chemical agents is scarce. the current study aimed to evaluate radiological findings of late onset pulmonary complications in chemical warfare victims (cwv) and to guide pulmonologists in diagnosis of these subjects.   materials and methods: ninety- three male cwv were enrolled in this prospective study, 20-25 years (mean=23) ...

BACKGROUND Ultrasound molecular imaging is a novel diagnostic approach for tumors, whose key link is the construction of targeted ultrasound contrast agents. However, available targeted ultrasound contrast agents for molecular imaging of tumors are only achieving imaging in blood pool or one type tumor. No targeted ultrasound contrast agents have realized targeted ultrasound molecular imaging o...

Mass spectrometry imaging (MSI) is a mass spectrometry based molecular ion imaging technique. It provides the means for ascertaining the spatial distribution of a large variety of analytes directly on tissue sample surfaces without any labeling or staining agents. These advantages make it an attractive molecular histology tool in medical, pharmaceutical, and biological research. Likewise, MSI h...

Introduction: To prevention the healthy tissues from irreversible damages, monitoring the temperature variation of healthy tissues is critical parameter during thermal therapies. Electrical impedance tomography (EIT) is considered as a real time imaging modality for monitoring the temperature but researches show that it suffers from low temperature resolution. In this study usi...