Vitiligo is an autoimmune disease characterized by depigmented lesions on the skin, and T-cell mediated in that cytotoxic T-cells kill melanocytes, resulting lesional areas of skin depigmentation. Interferon gamma (IFN-γ) proposed to play a key role pathogenesis vitiligo. The Janus kinase (JAK)-signal transducer activator transcription factor (STAT) pathway downstream activated IFN-γ, thus util...

The paper discusses a range of modern time series methods that have become popular in the past 20 years and considers their usefulness for cliometrics research both in theory and via a range of applications. Issues such as, spurious regression, unit roots, cointegration, persistence, causality, structural time series methods, including time varying parameter models, are introduced as are the es...

The structure of ortho-vanillin, C(8)H(8)O(3), has been revisited with modern methods and at low temperature (100 K). The previous structure [Iwasaki et al. (1976 ▶). Acta Cryst. B32, 1264-1266] is confirmed, but geometric precision is improved by an order of magnitude. The C atom of the meth-oxy group lies close to the benzene ring plane, which is the most common geometry for -OMe groups lying...

3Mortimer, J. Amer. Chem. Soc., 44, 1416 (1922); 45, 633 (1923). 4 Hildebrand, J. H., and Jenks, C. A., Ibid., 42, 2180 (1920); 43, 2172 (1921); cf. also Ref. 2, p. 148. 5 Dorfman, M., and Hildebrand, J. H., Ibid., 49, 729 (1927). 6 Cf. Hildebrand, J. H., and Glasscock, B. L., Ibid., 31, 26 (1909). 7 Porter, A. W., Trans. Faraday Soc., 16, 336 (1921). 8 Cf. Ref. 2, p. 48. 9 Taylor, N. W., J. Am...

Systematic (IUPAC) name N-(4-amino-1-(1-(4-amino-1-oxo-1-(3,12,23-tris(2-aminoethyl)20-(1-hydroxyethyl)-6,9-diisobutyl-2,5,8,11,14,19,22-heptaoxo1,4,7,10,13,18-hexaazacyclotricosan-15-ylamino)butan-2-ylamino)3-hydroxybutan-2-ylamino)-1-oxobutan-2-yl)-N,5-dimethylheptanamide Identifiers CAS number 1264-72-8 [1] ATC code A07 AA10 [2] J01 XB01 [3] QJ51 XB01 [4] PubChem CID 5311054 [5] DrugBank APR...

The purpose of this memo is to document how the requirements for advancing a routing protocol from Draft Standard to full Standard have been satisfied by Border Gateway Protocol version 4 (BGP-4). This report satisfies the requirement for "the second report", as described in Section 6.0 of RFC 1264. In order to fulfill the requirement, this report augments RFC 1773 and describes additional know...