Bacterial gastroenteritis is a disease that is pervasive in both the developing and developed worlds. While for the most part bacterial gastroenteritis is self-limiting, identification of an etiological agent by bacterial stool culture is required for the management of patients with severe or prolonged diarrhea, symptoms consistent with invasive disease, or a history that may predict a complica...

We develop a unifed theory to study geometry of manifolds with different holonomy groups. They are classified by (1) real, complex, quaternion or octonion number they are defined over and (2) being special or not. Specialty is an orientation with respect to the corresponding normed algebra A. For example, special Riemannian A-manifolds are oriented Riemannian, Calabi-Yau, Hyperkähler and G2-man...

We reported herein the synthesis, antifungal activity, docking and in silico ADME prediction studies of four novel series of sulfones 6a-f, 8a-c, 10a-f and 12a-c. All the newly synthesized sulfones were tested against four strains of Candida (including fluconazole-resistant Candida), two strains of Aspergillus, two dermatophytic fungi (Trichophytons mentagrophyte and Microsporum canis) and Sync...

Bis diacetylpyridine derivative (1) was prepared and reacted with different halo-compounds, namely: epichlorohydrine and dichloroethyl ethyl ether to give 2a,b, respectively, and reacted with morpholine and piperidine to afford Mannich products 3a,b, successively. Compound 4 was synthesized by reaction of 1 with potassium thiocyanate. Reaction of 4 with 4-chlorobenzaldehyde, glucose and phthali...

Coupling of 2-benzylmalononitrile with aromatic diazonium salts afforded 3-phenyl-2-arylhydrazonopropanenitriles 4a,b, which were rearranged into 2-cyanoindoles 5a,b upon heating with ZnCl(2) in the presence of glacial acetic acid. The produced indole derivatives 5a,b can be successfully used as valuable precursors to synthesize 1,2,4-oxadiazolylindoles 8a,b. The reaction of arylhydrazononitril...

Our search for new polar f"siceccins biosynthetically related to fusicoccin A from the culture filtrate of isolate Niigata 2-A of a peach Fusicoccum canker fungus resutted in the iso]atiofi of new fusicoccins named fusicocci"s P and Q, and 3-epifusicoccins H and Q, together with 3'-deacetylf"sicoccin A and 16-Odemethyl-3-epifusicoccin J. The structures of fusicoccins P and Q, and of 3-epifuslco...

Several recent investigations indicate the existence of gender-related systematic trends in peer review proposals for observations on astronomical facilities. This includes National Radio Astronomy Observatory (NRAO) where there is evidence a gender imbalance rank with male principal investigators (PIs) favored over female PIs. Since semester 2017A (17A), NRAO has taken following steps: (1) inf...

5-Cyanoamino-4-imidazolecarboxamide 4a (R = CH2-O-CH2-CH2-OH) has been synthesized, purified, and fully characterized by MS, MS/MS, HRMS, IR spectroscopy, and by 1H and 13C NMR spectroscopy. It is shown that cyclization of 4a yields the guanine 6a and the isoguanine 12a. Our findings provide experimental evidence in support of our hypothesis that the formation of oxanine and xanthine in nitrosa...

Based on in vitro work with rat liver, we recently suggested that the peroxisomal fraction is most important for the oxidation of 3a,7a,12a-trihydroxy-5,8-cholestanoic acid (THCA) into cholic acid. The cerebro-hepato-renal syndrome of Zellweger is a fatal recessive autosomal disorder, the most characteristic histological feature of which is a virtual absence of peroxisomes in liver and kidneys....

The neurological complications of infection by the mosquito-borne Zika virus (ZIKV) include Guillain–Barré syndrome (GBS), an acute inflammatory demyelinating polyneuritis. GBS was first associated with recent ZIKV epidemics caused emergence Asian lineage in South Pacific. Here, we hypothesize that ZIKV-associated relates to a molecular mimicry between viral envelope E (E) protein and neural pr...