IMPORTANCE There is limited evidence supporting use of physical therapy for hip osteoarthritis. OBJECTIVE To determine efficacy of physical therapy on pain and physical function in patients with hip osteoarthritis. DESIGN, SETTING, AND PARTICIPANTS Randomized, placebo-controlled, participant- and assessor-blinded trial involving 102 community volunteers with hip pain levels of 40 or higher ...

Abstract Background Patellar instability (PI) often increases the possibility of lateral patellar dislocation and early osteoarthritis. The molecular mechanism articular cartilage degeneration during patellofemoral osteoarthritis (PFOA) still requires further investigation. However, it is known that NF-κB signaling pathway plays an important role in degeneration. aim this study was to investiga...

Objective: To determine the risk factors of knee osteoarthritis in young patients. Methods: A total 100 patients with diagnosis arthritis were included as cases and a similar number who presented to orthopedic clinic for reasons other than taken controls. study questionnaire was designed gather information regarding patient’s age, gender, body mass index, physical activity, smoking history inju...

OBJECTIVE To compare the safety and efficacy of a single intra-articular (IA) injection of a new cross-linked hyaluronic acid product, Gel-200, with phosphate buffered saline (PBS, control) in a multi-center randomized controlled trial in patients with symptomatic osteoarthritis (OA) of the knee. DESIGN Patients were randomized 2:1 to receive a single injection of Gel-200 or PBS, after joint ...

BACKGROUND The objective of this study was to evaluate the extent of stromal cell-derived factor-1's (SDF-1) involvement in the pathogenesis of idiopathic versus post-traumatic OA by comparing differences in synovial membrane morphology, SDF-1 synovial fluid (SF) concentrations, and matrix metalloproteinase-13 (MMP-13) SF concentrations. METHODS Thirty-six 3-month-old Hartley guinea pigs were...

Osteoarthritis (OA) is a degenerative joint disease characterized by progressive cartilage destruction, matrix degradation and bony changes. Subchondral bone alterations in osteoarthritis are associated with cartilage destruction. It has previously been demonstrated that osteoprotegerin (OPG) and receptor activator of nuclear factor κβ ligand (RANKL) mediate this process. The RANKL/OPG ratio is...

Background:  New discoveries about the pathophysiology changed the concept that all forms of osteoarthritis are alike; this lead to the delineation of different phenotypes such as age, trauma or obese related forms. We aim to compare soluble mediator profiles in primary knee and posttraumatic wrist osteoarthritis. Based on the general faster progression rate of wrist osteoarthritis, we hypothes...

background: traction has been suggested to be an effective treatment for symptoms of neck disorder in patients with no contraindications. however, according to previous researches, the effectiveness of traction is controversial, particularly compared to other conservative treatments. this trial was conducted to evaluate the effect of sustained traction, using an over-the-door home cervical trac...

[Purpose] The aim of this study was to investigate whether neuropathic pain is associated with femoral condylar cartilage thickness, electrical pain threshold, and clinical parameters in patients with knee osteoarthritis. [Subjects and Methods] Sixty patients over the age of 40 diagnosed with knee osteoarthritis were enrolled. The PainDETECT questionnaire, Western Ontario and McMaster Universit...