The role of thallium-201 (201TI) scintigraphy in the follow-up evaluation of differentiated thyroid carcinoma (DTC) is controversial. Desirable characteristics of 201TI scintigraphy including the potential for no thyroid hormone withdrawal, immediate imaging postinjection, and low radiation burden relative to iodine-131 (131I) suggests it is logistically superior to 131I scintigraphy. Fifty-two...

OBJECTIVE Dosimetry studies have shown that activities of 131I as small as 10-20 MBq may cause a stunning effect. A result of this stunning effect may be a lower success rate of the ablative 131I therapy for differentiated thyroid carcinoma (DTC). The aim of this study was to determine whether pre-therapeutic uptake measurement with 40 MBq 131I causes a lower success rate of ablation. DESIGN ...

The conventional course of differentiated thyroid cancer (DTC) treatment requires surgical resection followed by radioactive iodine (131I) therapy (RAIT). Patients are advised to drink plenty water, as 131I gets eliminated through the kidneys and burden extra radiation is reduced. Treating a case DTC with chronic kidney disease (CKD) RAIT challenging. As result, when planning hemodialysis in pa...

Background: Anti-thyroid drugs (ATD) are routinely used in Australian practice as first-line therapy for Graves’ hyperthyroidism (GH) prior to 131I (radioiodine) treatment. There is concern that patients who do not receive ATD pre-treatment will develop uncontrolled hyperthyroidism before and after 131I therapy and that 131I therapy without ATD pre-treatment may not be as efficacious as with AT...

We compared the diagnostic sensitivities of 123I and 131I whole-body imaging in differentiated thyroid cancer. Methods: Twelve thyroidectomized patients (3 previously treated with 131I) were studied. After a period of thyroid hormone withdrawal, whole-body imaging was performed approximately 24 and 72–96 h after administration of 74 –185 MBq (2–5 mCi) 123I and 111–185 MBq (3–5 mCi) 131I, respec...

Relapsed B-cell lymphomas are incurable with conventional chemotherapy and radiation therapy, although a fraction of patients can be cured with high-dose chemoradiotherapy and autologous stem-cell transplantation (ASCT). We conducted a phase I/II trial to estimate the maximum tolerated dose (MTD) of iodine 131 ((131)I)-tositumomab (anti-CD20 antibody) that could be combined with etoposide and c...

BACKGROUND In our research,we study the effect of 131iodine-labeled histamine-indomethacin (131I-His-IN). We focus on its in vivo therapeutic effect and anti-tumor mechanisms in Lewis-bearing lung cancer. METHODS 131I-His-IN was administered by garage to the mice. At different timepoints, we made autoradiography (ARG) slices to observe the distribution of 131I-His-IN in the cellular, and the ...

A retrospective analysis of data from 73 consecutive patients with toxic multinodular goitre treated with iodine-131 (131I) during a 2-year period was performed to investigate if serum TSH at the time of 131I treatment influences the outcome. The dose of 131I was calculated according to a model compensating for thyroid size estimated by palpation and 24-h 131I uptake. Serum TSH was determined b...

OBJECTIVE The aims of this study were to quantify the extent of volatilization from 131I-NaI therapeutic capsules prepared in a centralized radiopharmacy and to quantify the amount of volatile 131I released from a dispensing vial containing a compounded 131I-NaI therapy capsule. METHODS Therapy capsules were prepared by injecting 131I oral solution into capsules containing anhydrous dibasic s...