INTRODUCTION Clinical trials of new treatments for rheumatoid arthritis (RA) typically require subjects to have an elevated acute phase reactant (APR), in addition to tender and swollen joints. However, despite the elevation of individual components of the Clinical Disease Activity Index (CDAI) (tender and swollen joint counts and patient and physician global assessment), some patients with act...

Abstract Introduction: The COVID-19 pandemic has affected the mental health of adults in United States (U.S.) due to recommended preventive behaviors such as social distancing. Our objective was evaluate symptoms and determinants among cancer survivors during U.S. Methods: We used nationally-representative data 10,760 from Impact Survey. defined a self-reported diagnosis (n = 854, 7.6%). estima...

Friedman, Mark I., Ruth B. Harris, Hong Ji, Israel Ramirez, and Michael G. Tordoff. Fatty acid oxidation affects food intake by altering hepatic energy status. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R1046–R1053, 1999.—Inhibition of fatty acid oxidation stimulates feeding behavior in rats. To determine whether a decrease in hepatic fatty acid oxidation triggers this beha...

Carlson, G. L., M. Saeed, R. A. Little, and M. H. Irving. Serum leptin concentrations and their relation to metabolic abnormalities in human sepsis. Am. J. Physiol. 276 (Endocrinol. Metab. 39): E658–E662, 1999.—Circulating leptin concentrations are raised in animal models of inflammation and sepsis. The purpose of this study was to determine the effect of sepsis on serum leptin concentration in...

Dall’Asta, Valeria, Ovidio Bussolati, Roberto Sala, Alessandro Parolari, Francesco Alamanni, Paolo Biglioli, and Gian C. Gazzola. Amino acids are compatible osmolytes for volume recovery after hypertonic shrinkage in vascular endothelial cells. Am. J. Physiol. 276 (Cell Physiol. 45): C865–C872, 1999.—The response to chronic hypertonic stress has been studied in human endothelial cells derived f...

Verberne, Anthony J. M., Daniela M. Sartor, and Ayse Berke. Midline medullary depressor responses are mediated by inhibition of RVLM sympathoexcitatory neurons in rats. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R1054–R1062, 1999.—Mechanisms underlying the depressor and sympathoinhibitory responses evoked from the caudal medullary raphe (MR) region were investigated in pent...

Saluja, A. K., L. Bhagat, H. S. Lee, M. Bhatia, J. L. Frossard, and M. L. Steer. Secretagogue-induced digestive enzyme activation and cell injury in rat pancreatic acini. Am. J. Physiol. 276 (Gastrointest. Liver Physiol. 39): G835–G842, 1999.—The mechanisms responsible for intrapancreatic digestive enzyme activation as well as the relationship between that activation and cell injury during panc...

Meddings, J. B., J. Jarand, S. J. Urbanski, J. Hardin, and D. G. Gall. Increased gastrointestinal permeability is an early lesion in the spontaneously diabetic BB rat. Am. J. Physiol. 276 (Gastrointest. Liver Physiol. 39): G951–G957, 1999.—The BB rat spontaneously develops autoimmune diabetes. Feeding these animals a hydrolyzed casein diet significantly reduces the incidence of this disease, su...

Horská, Alena, Larry J. Brant, Donald K. Ingram, Richard G. Hansford, George S. Roth, and Richard G. S. Spencer. Effect of long-term caloric restriction and exercise on muscle bioenergetics and force development in rats. Am. J. Physiol. 276 (Endocrinol. Metab. 39): E766–E773, 1999.—We evaluated the hypothesis that long-term caloric restriction and exercise would have beneficial effects on muscl...

Kozma, Fruzsina, Robert A. Johnson, Fan Zhang, Changhua Yu, Xianglan Tong, and Alberto Nasjletti. Contribution of endogenous carbon monoxide to regulation of diameter in resistance vessels. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R1087–R1094, 1999.— Endogenous carbon monoxide was proposed to subserve vasodepressor functions. If so, inhibition of heme oxygenase may be exp...