LASSBio-1524 was designed as inhibitor of the IKK-β (kappa β kinase inhibitor) enzyme, which participates in the activation of the nuclear factor κB (NF-κB) canonical pathway, and its three N-acylhydrazone new analogues, LASSBio-1760, LASSBio-1763 and LASSBio-1764 are now being tested on their anti-inflammatory potential. The activity of these compounds was evaluated with the subcutaneous air p...

Introduction: More than 350 million people are chronic carriers of HBV and many of them develop progressive diseases, including cirrhosis and hepatocellular carcinoma. Many of those infected develop persistent disease and a proportion goes on to develop liver failure and cancer. Researchers showed that double mutations of the x gene at position 1762 and 1764, have been found in chronic hepatiti...

The dependence of the optimal nonlinear filter on it's initial conditions is considered for continuous time linear filtering and for finite state space nonlinear filtering. Partial results are obtained in the high signal to noise ration case, together with a characterization of the Lyapunov exponent in the (easier) low SNR case. This work was supported in part by the Air Force Office of Scienti...