D. Coman, L. Jiang, F. Hyder, and K. Behar Department of Diagnostic Radiology, Yale University, New Haven, CT, United States, Quantitative Neuroscience with Magnetic Resonance (QNMR), Yale University, New Haven, CT, United States, Departments of Diagnostic Radiology and Biomedical Engineering, Yale University, New Haven, CT, United States, Department of Psychiatry, Yale University, New Haven, C...

The title compound, 5-(1H-indol-3-yl)-1-methyl-3-phenyl-1,6-benzodiazocin-2(1H)-one, was synthesized for the first time by a one-step, two-component reaction between 1-methylbenzimidazole and benzoylindolyl-3-acetylene. product characterized 1H-NMR, 13C-NMR, IR spectroscopy HRMS.

Sarcophyton sp. soft corals are rich in cembranoid diterpenes, which represent the main chemical defense of corals against their natural predators in addition to their myriad biological effects in humans. Quantitative NMR (qNMR) was applied for assessing the diterpene variation in 16 soft coral specimens in the context of their genotype, origin, and growing habitat. qNMR revealed high diterpene...

Dario J. Englot,1 Asht M. Mishra,1 Peter K. Mansuripur,1 Peter Herman,2,6,7 Fahmeed Hyder,2,3,6,7 and Hal Blumenfeld1,4,5,6 Departments of 1Neurology, 2Diagnostic Radiology, 3Biomedical Engineering, 4Neurobiology, and 5Neurosurgery, 6Program for Quantitative Neuroscience with Magnetic Resonance (QNMR), and 7Magnetic Resonance Research Center (MRRC), Yale University School of Medicine, New Haven...

Six organometallic complexes of the general formula [M(II)Cl(η(6)-p-cymene)(L)]Cl, where M = Ru (11a, 12a, 13a) or Os (11b, 12b, 13b) and L = 3-(1H-benzimidazol-2-yl)-1H-pyrazolo[3,4-b]pyridines (L1-L3) have been synthesized. The latter are known as potential cyclin-dependent kinase (Cdk) inhibitors. All compounds have been comprehensively characterized by elemental analysis, one- and two-dimen...

introduction: the aim of this study was to evaluate the changes in camp and some other cellular ingredients following adenyl cyclase activation in paragigantocellularis (pgi) neurons of morphine dependent and withdrawn rats. material and methods: the 3.5 mm thick brainstem slice prepared from pgi area (-10.04 to -13.24 from bregma) of control and morphine dependent rats (n=5 in each group). wer...

Nearly complete 1H, 13C and 15N NMR assignments have been obtained for a doubly labeled 14-base pair DNA duplex in solution both in the free state and complexed with the uniformly 15N-labeled Antennapedia homeodomain. The DNA was either fully 13C, 15N-labeled or contained uniformly 13C, 15N-labeled nucleotides only at those positions which form the protein-DNA interface in the previously determ...

Reactions of benzoylpyruvate with a mixture of aromatic aldehydes and 5-amino-1,3,4-thiadizole-2-thiol in a 1:1:1 molar ratio, afforded 5-(5-aryl-4-benzoyl-3-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-1,3,4-thiadizole-2-thiols (3a-c). The structure of the resulted products was confirmed by determination of the melting point and spectrophotometric techniques such as IR and 1H-NMR spectroscopy.