The potent hepatotoxin and carcinogen aflatoxin B1 (AFB1) is a common mycotoxin contaminant of grains used in animal feeds. Aflatoxin M1 (AFM1) is the major metabolite of AFB1 in mammals, being partially excreted into milk, and is a possible human carcinogen. The maximum permitted concentration of AFM1 in cows' milk is 0.05 μg/kg in Israel and the European Union. Since milk yield and the carry-...

Aflatoxin B1 (AFB1) and its metabolite aflatoxin M1 (AFM1) are well-known carcinogens for humans and animals health. In this study, an ultra-high performance liquid chromatography linked with fluorescence detection (UPLC-FLD) method was optimized and validated. In addition, we investigated for the first time, the influence of curcumin on residue depletion of AFB1 and AFM1 in liver, kidney, and ...

Aflatoxin B1(AFB1) and total Aflatoxins (AFT) contaminated feed effect on aflatoxins residue level in eggs, muscles (breast, leg), organs (liver, kidney, gizzard) and excreted aflatoxins in chicken litter of layer hens were monitored. Laying hens were on four levels of aflatoxins for 6 weeks and monitored weekly for the change in both AFB1 and AFT levels. Pronouncedly, the AFB1 and AFT were det...

A study of the effect in rats of dichlorodiphenyl trichloroethane (DDT) on hepatocarcinogenesis that is initated by aflatoxin B1 (AFB1). In the first experiment, Buffalo rats were given a single oral dose of AFB1 (5 mg/kg) followed by dietary DDT (100 ppm) for 20 weeks. Neoplastic nodules were observed in 1 of the 14 AFB1-exposed rats, compared with 3 of the 19 rats in the AFB1/DDT group. In th...

Aflatoxins (AFs) are highly toxic secondary metabolites produced by several Aspergillus, Penicillium and Rhizopus species in crops and plant products, of which aflatoxin B1 (AFB1) is the most representative (Goldblatt, 1969). If AFB1 is present in the feed of lactating animals, they will excrete aflatoxin M1 (AFM1) into their milk (Allcroft and Carnaghan, 1963; Cupid et al., 2004; Battacone et ...

This study investigated the presence of aflatoxin M1 (AfM1) in dairy cows' milk, given predefined scenarios for milk production, compound feed (CF) contamination with aflatoxin B1 (AfB1), and inclusion rates of ingredients, using Monte Carlo simulation modelling. The model simulated a typical dairy farm in the Netherlands. Six different scenarios were considered, based on two lactation and thre...

The aim of this study was to evaluate the ability of date pits (DP) to reduce the deleterious effects of aflatoxin B1 (AFB1) in broiler chicks. A total of 216 one-day-old male broiler chicks (Ross 308) were distributed randomly for nine treatments (with four replicates and six birds in each) for 35 days. The experiment included a 3×3 factorial arrangement of treatments involving three levels of...

Natural toxins in food are of increasing concern for human health. Among the natural toxins, mycotoxins pose a significant health risk within the tropical developing countries food supply chain [1]. Mycotoxins are produced by fungi (molds), such as Aspergillus, Fusarium, Penicillium and Alternaria, that are frequently present on agricultural products [2]. The contamination of foods and feeds by...