In order to determine the regularities of the structure-analgesic activity relationship, the peculiarities of obtaining, the spatial structure, and biological properties of 4-methyl-2,2-dioxo-1H-2λ⁶,1-benzothiazine-3-carboxylic acid and some of its derivatives have been studied. Using nuclear magnetic resonance (NMR) spectroscopy and X-ray diffraction analysis, it has been proven that varying t...

IN THE TITLE COMPOUND (SYSTEMATIC NAME 1,3,7-trimethyl-2,6-dioxo-7H-purin-9-ium hydrogen sulfate monohydrate), C(8)H(11)N(4)O(2) (+)·HSO(4) (-)·H(2)O, the crystal packing is stabilized through N-H⋯O and O-H⋯O hydrogen bonds.

A new, effective preparative method has been proposed and the synthesis of a series of N-(arylalkyl)-1-R-4-hydroxy-2,2-dioxo-1H-2λ(6),1-benzothiazine-3-car-boxamides has been carried out. It has been shown that amidation of alkyl 1-R-4-hydroxy-2,2-dioxo-1H-2λ(6),1-benzothiazine-3-carboxylates with arylalkyl-amines in boiling xylene proceeds with good yield and purity to the corresponding N-(ary...

As potential new analgesics, the corresponding 4-hydroxy-2,2-dioxo-1H-2λ⁶,1-benzothiazine-3-carboxanilides have been obtained by amidation of ethyl 4-hydroxy-2,2-dioxo-1H-2λ⁶,1-benzothiazine-3-carboxylate with aniline and its halogenated analogsin boiling dry xylene. The peculiarities of the mass and nuclear magnetic resonance (¹Н and 13С) spectra of the synthesized compounds are discussed. Usi...

A series of long-chain methyl esters with vicinal oxo groups (1,2-diones; 1,2-diketones) were synthesized by potassium permanganate-based oxidation of methyl esters of mono-unsaturated fatty acids. The presence of two additional carbonyl groups may facilitate the synthesis of other derivatives. The starting materials were selected in such a fashion to give the 1,2-dioxo moiety in consecutive po...

Three new sesquiterpene glycosides, possessing a rare aglycone with a sulfonyl between C-1 and C-15 positions, named 3-(3'E-7'R,8'-dihydroxy-4',8'-dimethyl-3'-nonenyl)-2,5-dihydro-1,1-dioxo-thiophen 7'-O-β-d-glucopyranosyl-(1→4)-O-β-d-glucopyranosyl-(1→4)-O-β-d-glucopyranoside (1), 3-(3'E-7'R,8'-dihydroxy-4',8'-dimethyl-3'-nonenyl)-2,5-dihydro-1,1-dioxo-thiophen 7'-O-β-d-glucopyranosyl-(1→4)-O-...

A novel fast, convenient and inexpensive synthesis of 1',3'-dioxo-1',3'-dihydrospiro[cyclopropane-1,2'-indene]-2,2,3,3-tetracarbonitrile and dimethyl 2,3-dicyano-1',3'-dioxo-1',3'-dihydrospiro[cyclopropane-1,2'-indene]-2,3-dicarboxylate is reported. These compounds undergo double carbanion cleavage under the action of alcohols resulting in the formation of stable salts, containing new allylic-t...

The reaction of dibenzoylacetylene with 4-alkylaminocoumarins in THF/H2O (50:50) lead to 4-(alkylamino)-3-(1,4-dioxo-1,4-diphenylbut-2-en-2-yl)-2H-chromen-2-one derivatives in good yields. When the reaction carried-out in DMSO the cyclized products 2-hydroxy-1-alkyl-3-(2-oxo-2-phenylethylidene)-2-phenyl-2,3-dihydrochromeno [4,3-b] pyrrol-4(1H)-ones were formed in good yields.

Abstract In this work, a functionalized gallium metal–organic framework with active dioxo-molybdenum (VI) centers was evaluated as catalyst in the epoxidation of soybean oil using tert-butyl-hydroperoxide an oxidizing agent. The influence reaction time, temperature, and concentration agent studied, it demonstrated that highest epoxide selectivity obtained at 110 °C after 4 h (29% conversion 91%...