Objective: The present work is based on the above pyrazoline derivative form heterocyclic substituted chalcone. Methods: elemental analysis, IR, 1H and 13C NMR mass spectrum analyses were used to characterise structures of obtained compounds. Results: scheme-1 scheme-2 describe synthesis chalcone (thiophene-fluorenyl derivative) pyrazolines respectively. Chalcone has been synthesized from 2-Ace...

Background: Infection with the Dengue virus can result in dengue fever (DD), which progress to hemorrhagic (DHF). Objective: In this work, molecule 3'-methoxy flavonol (3F) and its derivatives (T3F) were synthesized because they may be used develop antiviral DENV-2 NS2B/NS3 serine proteases. Method: Compound 2'-hydroxy-3-methoxy chalcone hydrogen peroxide are stirrer method synthesize compound ...

An efficient cyclization of 2’-hydroxychalcone to flavanone using calcium chloride as a catalyst was developed. The scope of the reaction was studied with substituted 2’-hydroxychalcone and these chalcones was converted into corresponding flavanone in good yield. The merits of this method are inexpensive and easily available catalyst, easy workup procedure, avoid use of toxic solvent