SUBJECTS, MATERIALS, AND METHODS DRUG ADMINISTRATION HALLUCINOGEN RATING SCALE STATISTICS RESULTS 0.4-MG/KG DOSE PERCEPTION SOMAESTHESIA AFFECT COGNITION VOLITION INTENSITY 0.2-MG/KG DOSE 0.1-MG/KG DOSE 0.05-MG/KG DOSE HALLUCINOGEN RATING SCALE TECHNICAL COMMENT ON ASSESSMENT OF SUBJECTIVE EFFECTS COMMENT REFERENCES

picralima nitida is used traditionally for management of cough. this study, therefore, investigated the antitussive, expectorant, and analgesic properties of the ethanolic seed extract of picralima nitida (pne), and ascertained its safety for use. presence of secondary metabolites, and safety of pne (10-2000 mg/kg) were evaluated by preliminary phytochemical screening, and by irwin’s test respe...

Objective: The objective of this study was to determine the acute toxicity and antidiabetic activity of the methanolic extract of Hygrophila auriculata in adult male Wistar rats. Methods: Methanolic extract was prepared by optimized maceration procedures. Then, they were administered to groups of six rats in doses of 0, 100, 500, 750, 1000 and 3000 mg/kg body weight. The rats were then observed...

Materials and methods: Performance and nutrient digestibility were determined for pigs consuming either water treated by reverse osmosis (RO; 219 mg total dissolved solutes (TDS) per L, 29 mg sulfates per L) or untreated ground water (3078 mg TDS per L, 1650 mg sulfates per L). In each of two experiments, approximately 240 pigs (20 ± 3 days of age, 5.9 ± 1.0 kg) received either RO-treated or un...

Copper (Cu) deficiency was diagnosed in a Norwegian red deer (Cervus elaphus) herd subsequent to deaths due to emaciation in late autumn 1999. The animals had free access to salt licks containing 3000 mg Cu/kg. An evaluation of the herd revealed poor calf growth rate, low weights of adult hinds, dull and light-coloured hair coats and cases of diarrhoea. The herd was subsequently monitored throu...

The growth of weaning piglets is effectively improved by feeding a high-Zn diet (3000 mg Zn/kg of diet). The present study examined whether feeding a diet supplemented with Zn (1016-3000 mg/kg) for 10 d induces growth benefits in rats. In addition, tissue weight, Zn content of tissues and expression of Zn transporters were examined in these rats. Zn supplementation did not significantly increas...

Objective: The study proposes using the dolomite buffer capacity (BCDolomite) as a method of estimating lime requirement in soils that agronomically require pH increase. Design/methodology/approach: In six soil samples with different levels response to application dolomite, organic matter (OM), content sand, silt and clay, pH, K, Ca, Mg potential acidity (Al+H) were determined. Assuming an appa...

In Thai traditional medicine, Moringa oleifera is used for the treatment of diabetes and hyperlipidemia. Oxidative stress plays a major role in the pathogenesis of many degenerative diseases, such as hyperlipidemia, diabetes mellitus, and cardiovascular disease. We evaluated the antioxidant effect of M. oleifera extract (MOE) for reduction of advanced glycation end-product (AGE) formation, cell...