نتایج جستجو برای: 215
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MicroRNA-215 (miR-215) promotes tumor growth in various human malignancies. However, its role has not yet been determined in human glioma. Here, we found that levels of miR-215 were higher in glioma tissues than in corresponding non-neoplastic brain tissue. High miR-215 expression was correlated with higher World Health Organization (WHO) grades and shorter overall survival. Multivariate and un...
SMG-1,a member of the phosphoinositide kinase-like kinase family, functioned as a tumor suppressor gene. However, the role of SMG-1 in GC remain uncharacterized. In this study, regulation of SMG-1 by miR-192 and-215, along with the biological effects of this modulation, were studied in GC. We used gene microarrays to screening and luciferase reporter assays were to verify the potential targets ...
The cytotoxic analog of bombesin (BN)/gastrin releasing peptide (GRP) AN-215 consisting of 2-pyrrolinodoxorubicin (AN-201), a superactive derivative of doxorubicin linked to a bombesin analog carrier, displays a high affinity to BN/GRP receptors and can be targeted to tumors that express these receptors. We evaluated the antitumor effect and the toxicity of AN-215 in 5 human breast cancer cell ...
We consider the following periodic sorting procedure on two-dimensional meshes of processors: Initially, each node contains one number. We proceed in rounds each round consisting of sorting the columns of the grid, and, in the second phase, of sorting the rows according to the snake-like ordering. We exactly characterize the number of rounds necessary to sort on an l m-grid in the worst case, w...
Epithelial ovarian cancer (EOC) accounts for 90% of all ovarian cancer, which is the third most common gynaecological malignancy worldwide. Dysregulation of miRNAs is involved in the development of different types of EOC. The present study was designed to investigate the role of abnormal expression of miR-215 in the development of EOC and to elucidate the possible molecular mechanisms. mRNA exp...
(a) Draw the Feynman diagram which gives the leading contribution to the process φφ→ φφ. (b) Derive the correct sign of the amplitude by considering the relevant matrix elements of powers of the interaction hamiltonian. (c) Evaluate the diagram in terms of a spinor trace and a momentum integral. Do not do the momentum integral. Suppose that the integral is cutoff at large k by some cutoff Λ. Es...
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This book is composed of contributions by participants in the weekly seminar of Harvard’s long-standing program in clinically relevant medical anthropology, and will stand as a mark of the program’s stature as a prime intellectual locus in which anthropological reflection on illness and suffering has generated results of profound significance for contemporary social thought. The volume is a wid...
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