نتایج جستجو برای: 22 dehydrocholesterol
تعداد نتایج: 212275 فیلتر نتایج به سال:
The three closely related sterols, cholesterol, 7-dehydrocholesterol and lathosterol, occur in animal tissues in different proportions. From their structures they would appear to be interconvertible by simple dehydrogenation or reduction steps as shown in Fig. 1, but unequivocal evidence for such a mechanism has not yet been obtained. It has generally been assumed that 7-dehydrocholesterol (pro...
To investigate whether novel pathways of vitamin D3 (D3) and 7-dehydrocholesterol (7DHC) metabolism initiated by CYP11A1 and previously characterized in vitro, occur in vivo, we analyzed samples of human serum and epidermis, and pig adrenals for the presence of intermediates and products of these pathways. We extracted human epidermis from 13 individuals and sera from 13 individuals and analyze...
Key Words: 14 15 Abbreviations: 16 BCA, bicinchoninic acid assay 17 DHCR24, 24 dehydrocholesterol reductase 18 DCM, dichloromethane 19 DMEM, Dulbecco's modified Eagle's medium 20 D 2 O, deuterium oxide 21 FCS, fetal calf serum 22 HS, horse serum 23 IA: isotopomer analysis 24 ISA, isotopomer spectral analysis 25 K-R, Kandutsch-Russell 26 LC, liquid chromatography 27 MeOH, methanol 28 MIDA, mass ...
The primary circulating form of vitamin D, 25-hydroxy-vitamin D [25(OH)D], is associated with multiple medical outcomes, including rickets, osteoporosis, multiple sclerosis and cancer. In a genome-wide association study (GWAS) of 4501 persons of European ancestry drawn from five cohorts, we identified single-nucleotide polymorphisms (SNPs) in the gene encoding group-specific component (vitamin ...
AIM OF THE STUDY Biochemical diagnosis of fetuses with multiple malformations--an attempt to determine the frequency of prenatal Smith-Lemli-Opitz syndrome. Discussion on trends in prenatal diagnosis of non-specific multiple malformations disorders. MATERIAL AND METHODS A total of 117 fetal samples were obtained. They were analyzed with gas chromatography/mass spectrometry (GC/MS) method to a...
The requirement of membrane cholesterol in maintaining ligand binding activity of the hippocampal serotonin(1A) receptor has previously been demonstrated. In order to test the stringency of the requirement of cholesterol, we depleted cholesterol from native hippocampal membranes followed by replenishment with 7-dehydrocholesterol. The latter sterol is an immediate biosynthetic precursor of chol...
Smith-Lemli-Opitz syndrome, a severe developmental disorder associated with multiple congenital anomalies, is caused by a defect of cholesterol biosynthesis. Low cholesterol and high concentrations of its direct precursor, 7-dehydrocholesterol, in plasma and tissues are the diagnostic biochemical hallmarks of the syndrome. The plasma sterol concentrations correlate with severity and disease out...
Vitamin D is well characterized for its role in mineral homeostasis and maintenance of normal skeletal architecture. Vitamin D has been demonstrated to exert anti-inflammatory effects in a variety of disease states including diabetes, arthritis and inflammatory bowel disease. In these diseases poly[adenosine diphosphate (ADP)-ribose] polymerase (PARP) inhibitors have also proved effective as an...
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