Ulcerative colitis (UC), characterized by inflammation, oxidative stress, and increased intestinal epithelial cell apoptosis, is an immunologically mediated chronic intestinal disorder. The present study was aimed at investigating the protective effects of alpha-lipoic acid (ALA) against trinitrobenzene sulfonic acid (TNBS)-induced UC and the underlying mechanism. ALA of 80 mg/kg bw/day was adm...

Abstract Inappropriate activation of the NLRP3 inflammasome has been implicated in multiple inflammatory diseases, including bowel disease. Herein, we discovered a series potent and selective inhibitors with non-sulfonylurea analogue. TTS-X, lead compound identified from this series, was found to bind directly cells by chemical proteomics study. It exhibited specific inhibition against IL-1β pr...