The present study seeks to identify the nutritional risk factors involved in the development of neuropathies induced by chemotherapeutic treatments. Unlike the gastrointestinal or hematological adverse effects of chemotherapy there is no protective treatment strategy for polyneuropathy. The aim of this study was to find possible deficiencies in nutritional factors, which can be used for supplem...

The basal level of the gene expression and the activity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase was higher in SV40-transformed human fibroblasts (90-VA VI) than in normal ones (HDF). In both these cell types mevinolin (25 microM) caused an 85-90% depression of HMG CoA reductase activity and of the incorporation of [3H]acetate into sterols. In HDF this was coupled to an effi...

OBJECTIVE Vitamin D is a fat-soluble secosteroid hormone that regulates calcium, magnesium, and phosphate homeostasis and plays a pivotal role as antiproliferative and immunomodulatory mediator. Considering the different sources of synthesis and dietary intake as well as the pleiotropic actions in extremely diverse (micro)environments of the body, the supplementation of this Vitamin should be c...

Giãn bạch mạch ruột tiên phát (PIL) là một rối loạn giãn bẩm sinh, hiếm gặp. Các triệu chứng lâm sàng của bệnh gây ra do mất quá nhiều dịch huyết vào lòng ruột, bao gồm protein, chất béo và tế bào lympho. Chúng tôi báo cáo trường hợp trẻ nữ, 14 tuổi, biểu hiện tiêu chảy kéo dài phù hai chân. Trẻ có tiền sử phẫu thuật cắt u mạc treo lúc 3 tuổi; đợt, xuất từ sau năm. Xét nghiệm cho thấy giảm albu...