Three novel multiflorane-type triterpenoids, 3α-p-nitrobenzoylmultiflora-7:9(11)-diene-29-benzoate (1), 3α-acetoxymultiflora-7:9(11)-diene-29-benzoate (2), and 3α-acetoxymultiflora-5(6):7:9(11)-triene-29-benzoate (3), along with two known related compounds 4 and 5 were isolated from the seeds of zucchini (Cucurbita pepo L). Their structures were determined on the basis of 1D and 2D NMR spectros...

BACKGROUND The first identified susceptibility gene for Crohn's disease, NOD2, acts as a sensor for the bacterial-wall peptidoglycan fragment muramyl dipeptide (MDP) and activates the transcription factor nuclear factor-κB (NF-κB). Upon NF-κB activation, intestinal macrophages (IMACs) induce expression of macrophage inflammatory protein (MIP)-3α to attract memory T lymphocytes. We therefore inv...

Overexpression or activation of cyclic AMP-response element-binding protein (CREB) has been known to be involved in several human malignancies, including lung cancer. Genes regulated by CREB have been reported to suppress apoptosis, induce cell proliferation, inflammation, and tumor metastasis. However, the critical target genes of CREB in lung cancer have not been well understood. Here, we ide...

Glycogen synthase kinase-3 (Gsk-3) activity is an important regulator of numerous signal transduction pathways. Gsk-3 activity is the sum of two largely redundant proteins, Gsk-3α and Gsk-3β, and in general, Gsk-3 is a negative regulator of cellular signaling. Genetic deletion of both Gsk-3α and Gsk-3β in mouse embryonic stem cells (ESCs) has previously been shown to lead to the constitutive ac...

Для реакцiї 14N(γ, np)3α виконано аналiз розподiлiв за енергiєю збудження 2x i 3x α-частинок. В α-частинковому розподiлi виявлено видiлено канал утворення основного стану ядра 8Ве. подiй, що вiдповiдають цьому каналу, побудовано розподiл трьох У бiляпороговiй 3α-частинковiй областi максимум, який може вiдповiдати Хойла 12C. Видiлено подiї, парцiальному каналу np)12C*(0+) з наступним двочастинко...

The GABAergic neuroactive steroid (3α,5α)-3-hydroxy-pregnan-20-one (3α,5α-THP, allopregnanolone) is decreased in various brain regions of C57BL/6J mice following exposure to an acute stressor or chronic intermittent ethanol (CIE) exposure and withdrawal. It is well established that there are complex interactions between stress and ethanol drinking, with mixed literature regarding the effects of...

Reliable molecular markers are essential for a better understanding of the molecular epidemiology of Plasmodium vivax, which is a neglected human malaria parasite. The aim of this study was to analyze the genetic diversity of P. vivax isolates from the Brazilian Amazon using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis of the highly polymorphic merozoit...

Abstract Macrophage inflammatory protein-3, or MIP-3α, is a chemokine that highly expressed in gliomas, with expression progressively increasing tumor grade. It one of the top genes pseudopalisading and perinecrotic zones glioblastoma (GBM) as chemokine, can greatly influence tumor-immune interactions. The receptor for CCR6, found on variety GBM-infiltrating immune subsets such γδ T cells, conv...

Progesterone is the predominant gestagen in most mammals studied so far. It plays a substantial role regulation of female reproductive cycle and providing support for pregnancy maintenance. Despite its known functions, gaps knowledge are present regarding reduced metabolites that potentially exert biological activity. Therefore, new UHPLC-HRMS method based on Q Exactive™ mass spectrometer was d...

Sulforaphane increases the expression of dihydrotestosterone (DHT)-degrading enzyme, 3α-hydroxysteroid dehydrogenase (3α-HSD) in liver, which accelerates DHT degradation, thereby inhibiting hair loss animal model. In this study, we elucidated its underlying mechanism and demonstrated that sulforaphane has inhibitory functions RAW264.7 macrophage cells Hepa1c1c7 at cellular gene levels. The leve...