The Pd(TFA)2-catalyzed [4+1] annulation of chained or cyclic α-alkenyl-dicarbonyl compounds and unprotected primary amines for “one-pot” synthesis of pyrroles is reported here. Enamination and amino-alkene were involved in this practical and efficient tandem reaction. The annulation products were isolated in moderate to excellent yields with O2 as the terminal oxidant under mild conditions. In ...

Iron (III) phosphate catalyzed condensation reaction of aldehydes, 1,3-dicarbonyl compounds and amuniom acetate refluxing ethanol that remains a common theme in current literature.

A novel metal-free approach to construct the tetrasubstituted furans from Morita-Baylis-Hillman (MBH)-carbonates of acetylenic aldehydes has been developed. This strategy involves the cascade nucleophilic substitution/5-exo-dig-cycloisomerization of MBH-carbonates with 1,3-dicarbonyl compounds to give uniquely substituted 2-furan-3-yl acrylates. Additionally, the obtained furan adducts open a n...

A base-promoted one-pot tandem reaction sequence has been developed to transform electron-deficient chromone-fused dienes 1 and 1,3-dicarbonyl compounds 2 to functionalized 2-hydroxybenzophenones 3 under mild conditions. This domino process, which involves multiple reactions, including Michael addition/cyclization/elimination, serves as an efficient, economic, and eco-friendly method for the co...

In this research, we have developed cheap recyclable and task-specific acidic ionic liquids (AILs) 1-hydrogen-3-methylimidazolium hydrogen sulfate [Hmim]HSO4, 1-hydrogen-3-methylimidazolium chloride [Hmim]Cl, 2-pyrrolidonium hydrogensulfate [Hnhp]HSO4 and applied them in acid catalyzed synthesis of quinoxaline derivatives from 1,2-phenylendiamines and 1,2-dicarbonyl compounds. The products coul...

The reaction of 2-methylene-1,3-dicarbonyl compounds (1) with ethyl diazoacetate gave 4,5-dihydro-1H-pyrazole derivatives (2), which were stable for several months at room temperature in good yields.

An environmentally benign, fast and convenient protocol has been developed for the Michael addition of 1,3-dicarbonyl compounds to β-nitroalkenes in good to excellent yields by a grinding method under catalyst- and solvent-free conditions.

The generation of a small and representative library of 3,5,8-trisubstituted coumarins (21 compounds, 7 families, 3 groups) is described. The library was built from the corresponding propargyl vinyl ethers and three different 1,3-dicarbonyl derivatives using a one-pot coupled domino strategy. These coumarins constitute a novel chemotype defined by the presence of a chemical handle in the pyrano...

A new synthesis of esters of 2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acids and some related compounds has been developed. The synthesis is based on reaction of atosyl-substituted phenyl carbamates with enolates of b-oxoesters or 1,3-dicarbonyl compounds followed by treatment of the obtained products with ammonia and dehydration of the resulting 4-hydroxyhexahydropyrimidin-2-ones.

Easily synthesized1-methyl-3-(2-oxyethyl)-1H-imidazol-3-ium-borate sulfonic acid {[MOEI]-BSA} as a novel catalyst efficiently promoted the synthesis of quinoxaline derivatives via condensation of various diamines with 1,2-dicarbonyl compounds at room temperature conditions in ethanol. This research provides a new method for the synthesis of quinoxalines in good to excellent yields with little c...