In order to ascertain whether chemical alterations in cell surface glycopeptides may be associated with tumor progression, we isolated Sialoglycopeptide fractions from the surface of AS-30D rat ascites hepatoma cells before and after tumor progression. During the 70th to 90th transplantation generation of the AS-30D tumor, a morphological change and an increase in tumor virulence were observed....

Studies on insulin resistance of liver cells are often performed with the use of various hepatoma cell lines. Such an approach allows investigating selected biochemical pathways at the cellular level. However, possible modifications of metabolic processes due to the neoplastic nature of such cells must be considered. Expanding the diversity of hepatoma cell lines used in metabolic studies could...

In China, TianMai Xiaoke tablet (TM) is used to treat type 2 diabetes. However, the exact mechanism of TM is not clear. This study is to investigate the effect of TM on glucose metabolism in diabetic rats and to identify whether TM takes a direct action through microRNAs on islet. Rats were divided into control group, diabetic group, low dose of TM group (TML), and high dose of TM group (TMH). ...

In this study, solvent-cast polymeric films containing ionic liquid lidocaine/aspirin for transdermal patches were developed. Solvent-cast prepared from two polymers, pectin and Eudragit® NE 30D, by drying the solution in a hot air oven at 70 ± 3 °C 10 h. Glycerin was used as plasticizer. Lidocaine aspirin form loaded into patches. The physicomechanical properties of characterized texture analy...

Hexokinase type II is highly overexpressed in many cancer cells, where it plays a pivotal role in the high glycolytic phenotype. Here we demon strate by Southern blot analysis and fluorescence in situ hybridization (FISH) that in the rapidly growing rat AS-30D hepatoma cell line, en hanced hexokinase activity is associated with at least a 5-fold amplification of the type II gene relativeto norm...

Hexokinase type II is highly overexpressed in many cancer cells, where it plays a pivotal role in the high glycolytic phenotype. Here we demon strate by Southern blot analysis and fluorescence in situ hybridization (FISH) that in the rapidly growing rat AS-30D hepatoma cell line, en hanced hexokinase activity is associated with at least a 5-fold amplification of the type II gene relativeto norm...

The broken heart. You think you will die, but you just keep living, day after day after terrible day. 1 T here seem to be as many approaches to managing heart failure as there are causal factors. Heart failure management is evolving from a one-size-fits-all approach centered around therapy with neurohormonal antagonists toward strategies tailored to provide the optimal clinical benefit based on...

Abstract This is a 31-year retrospective cohort study aiming to evaluate the relationship between proportion of B. indicus genetics crossbred dams and weaning weight their calves. Our hypothesis was that with intermediate degree wean heavier calves than those low-to-high at subtropical condition. The cow-calf pairs (n = 4,901) were in six evenly distributed breed groups according Brahman: G0–19...

Baseline urinary creatinine excretion (UCE) is associated with ICU outcome, but its time course not known. We determined changes in UCE, plasma creatinine, measured clearance (mCC) and estimated glomerular filtration (eGFR) patients an ICU-stay ?30d without acute kidney injury stage 3. The Cockcroft-Gault, MDRD (modification of diet renal disease) CKD-EPI (chronic disease epidemiology collabora...