A diallel cross is a set of all possible matings between several genotypes, which may be individuals, clones, homozygous lines, etc. Such crosses are used to estimate general and specific combining abilities of lines and crosses respectively. For ‘n’ inbreed lines, the possible F1’s are n(n–1)/2, which are to be tested in a suitably replicated randomized design. With facilities available for te...

This paper considers the construction of minimum aberration (MA) blocked factorial designs. Based on coding theory, the concept of minimum moment aberration due to Xu (2003) for unblocked designs is extended to blocked designs. The coding theory approach studies designs in a row-wise fashion and therefore links blocked designs with nonregular and supersaturated designs. A lower bound on blocked...

BACKGROUND The 2 × 2 factorial design is widely used for assessing the existence of interaction and the extent of generalizability of two factors where each factor had only two levels. Accordingly, research problems associated with the main effects and interaction effects can be analyzed with the selected linear contrasts. METHODS To correct for the potential heterogeneity of variance structu...

A novel, supersaturable self-microemulsifying drug delivery system (S-SMEDDS) was successfully formulated to enhance the dissolution and oral absorption of valsartan (VST), a poorly water-soluble drug, while reducing the total quantity for administration. Poloxamer 407 is a selectable, supersaturating agent for VST-containing SMEDDS composed of 10% Capmul® MCM, 45% Tween® 20, and 45% Transcutol...

Non-regular two-level fractional factorial designs, such as Plackett–Burman designs, are becoming popular choices in many areas of scientific investigation due to their run size economy and flexibility. The run size of nonregular two-level factorial designs is a multiple of 4. They fill the gaps left by the regular twolevel fractional factorial designs whose run size is always a power of 2 (4, ...