Mcl-1 is a member of the Bcl-2 family protein; its degradation is required for the initiation of apoptosis. The mechanism, however, is not yet clearly known. Previously, it was reported that Mcl-1 is degraded through the ubiquitination-mediated pathway and the PEST domain is the motif responsible for promoting this degradation. We found evidence that this may not be true. We generated several M...

Among 73 clinical isolates of Pseudomonas aeruginosa 48 strains were ciprofloxacine (CIP) susceptible and 25 CIP resistant (Minimal inhibitory concentration--MIC>32 microg/ml - 14 strains) or of intermediate susceptibility to CIP (MIC > or = 1,5 - 32 microg/ml - 11 isolates). Mutations in the quinolone-resistance-determining region (QRDR) of gyrA gene were searched in groups of CIP resistant an...

Assuming the deleterious mutations in the Penna ageing model to affect mainly the young ages, we get an enhanced mortality at very young age, followed by a minimum of the mortality, and then the usual exponential increase of mortality with age. The standard Penna ageing model, based on strings of 32 bits for each individual, gives good agreement with human mortality at middle and old age a, whe...

Congenital hyperinsulinism (CHI) has been mostly associated with mutations in seven major genes. We retrospectively reviewed a cohort of 32 patients with CHI. Extensive mutational analysis (ABCC8,KCNJ11,GCK,GLUD1,HADH,HNF4A, and UCP2) was performed on Ion torrent platform, which could analyze hundreds of genes simultaneously with ultrahigh-multiplex PCR using up to 6144 primer pairs in a single...

NACTIVATION of bacteria and bacteriophages by decay of incorporated radio‘active phosphorus (P”) has been reported by STENT and FUERST (1955), FUERST and STENT (1956), STRAUSS, VAHARU, FRICKEY and MATHESON (1956), TESSMAN, TESSMAN and STENT (1957), MCFALL, PARDEE and STENT (1958), and KAUDEWITZ, VIELMETTER and FRIEDRICH-FREKSA ( 1958). These authors have suggested that the P32 disintegrations w...

There are very few studies about K-ras mutations in colorectal cancer (CRC) from developing countries such as Iran. It is therefore essential to conduct studies to learn about the molecular signature of such tumors, allowing the determination of an appropriate management plan. In the present study, we aimed to determine the frequency and types of K-ras mutations among patients with CRC in Iran....

The H'mong short tail dog is breed indigenous dogs, distributed in mountainousareas of northern Vietnam. possesses many valuable properties such as intelligence, agility, good health, shape, human friendliness, ease training and it can fully meet the needs war Dogs strength, parenting, people friendly more importantly, still keeping wild characteristics hunting dogs. total 45 samples (blood) co...