The aberrant accumulation of tau protein is a pathological hallmark of a class of neurodegenerative diseases known as tauopathies, including Alzheimer's disease and related dementias. On the basis of previous observations that tau is a direct substrate of histone deacetylase 6 (HDAC6), we sought to map all HDAC6-responsive sites in tau and determine how acetylation in a site-specific manner aff...

The title compound, C22H22ClN3O5 {systematic name: 2-(propan-2-yl-idene-amino-oxy)ethyl (R)-2-[4-(6-chloro-quin-oxalin-2-yl-oxy)phen-oxy]propionate}, is a herbicide. The asymmetric unit comprises two independent mol-ecules in which the dihedral angles between the phenyl ring and the quinoxaline ring plane are 75.93 (7) and 82.77 (8)°. The crystal structure features C-H⋯O, C-H⋯N, and C-H⋯Cl hydr...

BACKGROUND A number of studies have indicated regional differences in semen quality. To examine the current status in Japan, we undertook a cross-sectional study on the semen quality of fertile Japanese men for comparison with recent European results. METHODS Semen parameters of 324 fertile men from the Kawasaki/Yokohama area were investigated. The semen parameters were compared with those pu...

عاطقلا طبر ي يذ لا ة يبرهكلا ىو قلا ماظنل يكيمانيدلارارقتسلال ةضيفتسم ةيلمع ةسارد ثحبلا اذه مدقي ني ب ة لوقنملا ةرد قلا ةدا يز ى لع ك لذ ريثأ ت و ةيدوعس لا ءا برهآ ةآر ش ن م ط سولأا عا طقلا و يقرش لا نيعاطقلا ، ىوقلا مظن تاتبثم طبض للاخ نم كلذو . دقل شم ةغايص مت ةلك طبض ةروص ىف تاتبثملا هذه ةلثمأ ةلكشم . ماظنلا ءادأ نيسحتل ك لذو ةدر فنملا ماظنلا ميق ىلع نادمتعت فده يتلاد حارتقا مت دقلو . د قلو ...

MicroRNAs (miRNAs) are known to repress translation by binding to the 3'UTRs of mRNAs. Using bioinformatics, we recently reported that several miRNAs also have target sites in DNA particularly in the promoters of the protein-coding genes. To understand the functional significance of this phenomenon, we tested the effects of miR-324-3p binding to RelA promoter. In PC12 cells, co-transfection wit...

Emerging evidence indicates that microRNAs, a class of small and well-conserved noncoding RNAs, participate in many physiological and pathological processes. RNase III endonuclease DICER is one of the key enzymes for microRNA biogenesis. Here, we found that DICER was downregulated in tumor samples of colorectal cancer (CRC) patients at both mRNA and protein levels. Importantly, intestinal epith...

www.sciencemag.org (this information is current as of April 6, 2009 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/324/5923/98 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/324/5923/98/DC1 can be found at:...

AMA Wysokińska M, Kołota A. The level of consumers’ knowledge on the influence ethyl alcohol health – a review literature. Alcoholism and Drug Addiction/Alkoholizm i Narkomania. 2022;35(4):307-324. doi:10.5114/ain.2022.126947. APA Wysokińska, M., & Kołota, (2022). Narkomania, 35(4), 307-324. https://doi.org/10.5114/ain.2022.126947 Chicago Martyna, Aleksandra Kołota. 2022. "The literature". Nark...