Symbolic reasoning about continuous dynamic systems requires consistent qualitative abstraction functions and a consistent symbolic model. Classically, symbolic reasoning systems have utilized a box partition of the system space to achieve qualitative abstraction, but boxes can not provide a consistent abstraction. Our Q2 methodology abstracts a provably consistent symbolic representation of no...

Translation control often operates via remodeling of messenger ribonucleoprotein particles. The poly(A) binding protein (PABP) simultaneously interacts with the 3' poly(A) tail of the mRNA and the eukaryotic translation initiation factor 4G (eIF4G) to stimulate translation. PABP also promotes miRNA-dependent deadenylation and translational repression of target mRNAs. We demonstrate that isoform...

The in vivo efficacy of JNJ-Q2, a new broad-spectrum fluoroquinolone (FQ), was evaluated in a murine septicemia model with methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA) and in a Streptococcus pneumoniae lower respiratory tract infection model. JNJ-Q2 and comparators were also evaluated in an acute murine skin infection model using a community-ac...

The dependence on Q2 (the negative square of the 4-momentum of the exchanged virtual photon) of the generalised Gerasimov–Drell–Hearn integral for the proton has been measured in the range 1.2 GeV2 < Q2 < 12 GeV2 by scattering longitudinally polarised positrons on a longitudinally polarised hydrogen gas target. The contributions of the nucleon-resonance and deep inelastic regions to this integr...

In this paper, we first give the maximal and minimal values of the ranks and inertias of the quadratic matrix functions q1(X) = Q1 − XP1X and q2(X) = Q2 − XP2X subject to a consistent matrix equation AX = B, where Q1, Q2, P1 and P2 are Hermitian matrices. As applications, we derive necessary and sufficient conditions for the solution of AX = B to satisfy the quadratic equality XP1X ∗ = Q1 and X...

A length n group code over a group G is a subgroup of G under component-wise group operation. Two-level group codes over the class of generalized quaternion groups, Q2 ; m 3, are constructed using a binary code and a code over Z 2 , the ring of integers modulo 2 m , as component codes and a mapping f from Z2 Z2 to Q2 . A set of necessary and sufficient conditions on the component codes is deriv...