The efficacy of present day antineoplastic regimens depends upon the delivery and penetration of therapeutic agents through the tumor vas cular and interstitial spaces to the tumor cell target. The distribution of relevant molecules or cells in a solid tumor is often poor and heteroge neous and is believed to be due to a number of pathophysiological factors, including elevated interstitial flui...

compounds were /V-acetylcysteine, bismuththiol. calcium glucarate, (±) catechin, diallyl disulfide, glycaric acid, i>-glucaro-l,4-lactone. \-(4hydro\yphenyl)retinamide, n-limonene, mesna, retinole acid, rutin, quercetin, silymarin, and taurine. In examining the nature of compounds that inhibited rat trachea! epithelial cell transformation, several possible chemoprevcntivc mechanisms appeared t...

Studies on GSK3¥â expression in the kainate induced excitototoxic hippocampal injury model of mice Jung Hoon Lee Department of Anatomy Graduate School Seoul National University Glycogen synthase kinase 3¥â (GSK3¥â) is believed to play important roles in the regulation of synaptic plasticity, cell survival and circadian rhythms in the mature CNS. However, although several studies have been focus...

homoalcophosphamide by the procedure of Corey and Kim (7) gave diethylaldophosphamide and diethylhomoaldophos phamide, respectively (Chart 2). Diethylaldophosphamide was characterized by mass spectral analysis [m/e 283, 1 Cl, M2— CH2C1@; m/e 192, no Cl, M —N(CH2CH2C1)2] and by positive qualitative tests as an aldehyde and an alkylating agent. Complete purification of diethylaldophosphamide ...

The immunization of rabbits with cells of mouse leukemia L1210 has been studied. The immune process was dissected into its †̃yMand †̃yGcomponents. The main objective was the preparation of antisera with high cytolytic potencies. A single i.v. injection of viable Ll2lO cells produced a classical immune response in rabbits, with -yM antibody activity first detected on Day 4, maximal on Day 6, a...

In hematological malignancies, homozygous deletion of @/6â@NK4A is primarily limited to ALL3 and non-Hodgkin's lymphoma (10—13). Although ALL has among the highest reported rates of homozygous deletion at 9p2l in primary neoplasia (6, 9—1, 14), assigning a tumor suppressor role to p16@―@4― alone in these malignancies is difficult, because most cases include both p15@―4'@and p16@―4â...

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Vitamin D3-binding protein (DBP; human DBP is known as Gc protein) is the precursor of macrophage activating factor (MAF). Treatment of mouse DBP with hnmobffized @3-galactosidase or treatment of human Gc protein with immobifized @-galactosidaseand sialidase generated a re markably potent MAF, termed DBPMAF or GCMAF, respectively. The domain of Ge protein responsible for macrophage activation w...

Purpose: With  increasing the usage  of  myocardial  perfusion  imaging  (MPI)  for  the diagnosis  of  ischemic  heart  disease,  we  aimed  to  evaluate  the  side  effects  of  low-dose  radiation  induced  by  this  technique  on blood elements, especially proteins and liver function factors.Materials and  Methods:  40  eligible  patients  (Mean  age:  54.6...