The Hantzsch reaction was adapted to allow the rapid radiosynthesis of 13N-labelled 1,4-dihydropyridines, including [13N]nifedipine, for preclinical PET imaging.

reactions of 1 ,zdihydropyridines (la-c) and 1,4-dihydropyridines (2a-c) in the presence of benzyne (3) under thermal conditions, and in the case of (2c) under photochemical conditions, have been investigated. benzyne acts as an oxidizing agent to convert dihydropyridine (la) and (2a) to the corresponding pyridine (4) or adds as a dienophile to (lb-c).

P-Glycoprotein, the plasma membrane protein responsible for the multidrug resistance of some tumour cells, is an active transporter of a number of structurally unrelated hydrophobic drugs. We have characterized the modulation of its ATPase activity by a multidrug-resistance-related cytotoxic drug, vinblastine, and different multidrug-resistance-reversing agents, verapamil and the dihydropyridin...

2-monobromomethyl 1,4-dihydropyridines is selectively synthesized by bromination of the parent compound by 1.1 equivalents of pyridinium bromide perbromide in dichloromethane/pyridine at -20 °c. the same reagent in dichloromethane at 0 °c produce the 2,6-bis(bromomethyl) 1,4-dihydropyridines.

objectives in order to provide a pharmacological profile for some newly synthesized dihydropyridines, we investigated their effects on the isolated rat colon segments and the isolated rat atrium contractility. the tested compounds include alkyl ester analogues of nifedipine, in which the ortho-nitrophenyl group at position 4 is replaced by 2-alkylthio-1-benzyl-5-imidazolyl substituent, and nife...

objective(s): the structure- activity relationship of a series of 36 molecules, showing l-type calcium channel blocking was studied using a qsar (quantitative structure–activity relationship) method. materials and methods: structures were optimized by the semi-empirical am1 quantum-chemical method which was also used to find structure-calcium channel blocking activity trends. several types of d...