an efficient and simple one-pot approach for the synthesis of 3,4-dihydropyrimidin-2-(1h)-one derivatives using antimony trichloride (sbcl3) as a mild catalyst by means of three-component biginelli reaction between β-keto esters, aldehyde derivatives and urea/thiourea under thermal and solvent-free conditions with excellent yields and short reaction times is reported. this methodology offers se...

alkali and alkaline earth metals hydrogen sulfate catalyzed the one-pot three component condensation reactions of aldehydes, 1,3-dicarbonyl compounds and urea or thiourea under solvent-free conditions leading to 3,4-dihydropyrimidin-2(1h)-ones in high yields at 80 °c. our results showed that biginelli reaction not only is ph dependent, but the cation of catalyst plays an important role.

d-tartaric acid is successfully used as a green and efficient catalyst for the synthesis of 3,4-dihydropyrimidin-2(1h)-ones under solvent-free conditions. the developed method has many advantages, including devoid of harmful catalyst and solvents, high yield and easily work-up.

In this study, an efficient and green process for the synthesis of dihydropyrimidin-2(1H)-ones from aromatic benzaldehydes, ethyl acetoacetate and urea using Al-MCM-41 as heterogeneous catalyst and microreactor under solvent-free conditions has been developed. The advantages of this method are easy work-up procedure, regeneration of the catalyst, clean and neutral reaction conditions.

A magnetic nanoparticle conjugated mesoporous nanocatalyst (Fe(3)O(4)@mesoporous SBA-15) with a high surface area has been synthesized by chemical conjugation of magnetite (Fe(3)O(4)) nanoparticles with functionalized mesoporous SBA-15. Functionalized mesoporous SBA-15 containing surface carboxyl and amino groups was synthesized via the thiol-ene click reaction of cysteine hydrochloride and vin...

In this work, the ionic liquid triethylamine-bonded sulfonic acid {[Et3N–SO3H]Cl}, N,N-diethyl-N-sulfoethanammonium chloride was used as a green acidic homogeneous catalyst to synthesis of 3,4-dihydropyrimidin-2(1H)-ones and 3,4-dihydropyrimidin-2(1H)-thiones as two categories of heterocycles, from aldehyde, dicarbonyl compound and urea or thiourea throughout the one-pot three components cycloc...

3,4-dihydropyrimidin-2(1H)-thiones were synthesized in the presence of Ag nanoparticle/melamine sulfonic acid (MSA) supported on silica gel. The reaction was carried out at 110 oC for 20 min under solvent free conditions. In all cases, the three component reaction proceeded smoothly to give the corresponding 3,4-dihydropyrimidin-2(1H)-thiones in moderate to good yield. We have found the best co...