HIE-124 is the new member of ultra-short acting hypnotics drug family. In this research, thiadiazole can act as the bio-isosteric replacement of thiazole in synthesized compounds as HIE-124 derivatives. HIE-124 drug, in which the heterocyclic thiazole ring replaced to thiadiazole, will be presented. Thiadiazolodiazepines were synthesized by a two-step reaction starting from the amino thiadiazol...

Thiadiazole and their derivatives have been studied extensively because of their wide range of biological activity. They are found to be effective as antibacterial, antimalarial, antiviral, antiinflammatory, anticancer and antianthelminthic agents. Diverse biological activities, such as antibacterial, anti-inflammatory, and antiviral have been associated with 1,3,4Thiadiazole derivatives. The s...

1,3,4-thiadiazole is one of the most potent heterocyclic containing carbonic anhydrase and antibacterial inhibitor from the natural and synthetic origin. It possessed potent anticonvulsant activity in wide range preclinical in vitro and in vivo models. Recently, various 1,3,4-thiadiazole derivatives have been synthesized and evaluated their anticonvulsant activity. This review is a demonstratio...

The chemistry of heterocyclic compounds has been an interesting field of study for a long time. Heterocyclic nucleus 1,3,4-thiadiazole constitutes an important class of compounds for new drug development. The synthesis of novel thiadiazole derivatives and investigation of their chemical and biological behavior have gained more importance in recent decades. The search for antiepileptic compounds...