The aim of the work. 1,2,4-triazole derivatives possess a wide range pharmacological activity, so they are used for development drugs and active pharmaceutical ingredients. Due to reactivity 1,2,4-triazoles there many options their further structural modification on different reaction centers. Therefore, work was obtain new S-substituted 1,2,4-triazole-3-thiols, study physicochemical parameters...

The reaction of equimolar equivalents 1-(4-methoxyphenyl)-5-methyl-1H-1,2,3-triazole-4-carbohydrazide (1) and 2-acetylbenzofuran (2) in anhydrous ethanol containing a catalytic amount concentrated hydrochloric acid under reflux for 2 h gave (E)-N’-(1-(benzofuran-2-yl)ethylidene)-1-(4-methoxyphenyl)-5-methyl-1H-1,2,3-triazole-4-carbohydrazide (3) 86% yield. structure the title heterocycle 3 was ...

Abstract Despite the remarkable progress in diagnostic and antifungal drugs research in past 10 years ,still complexity of the characteristics of patients continue to make the management of fungal infection is a great challenge .1,2,4-triazole compounds not only offer an interesting chemistry but also their various derivatives possesses diverse chemotherapeutic activity. The recent literatures ...

A. S. Shawali, M. A . A bdallah , and M. E. M. Z ay ed Department of Chemistry, Faculty of Science, University of Cairo, Giza, Egypt Reprint requests to Dr. A. S. Shawali. E-mail: [email protected] Z. Naturforsch. 55b, 546-552 (2000); received February 4. 2000 Ring-Chain Tautomerism. Heterocyclic Ring Transformation, 1,3,4-Thiadiazoles The synthesis and antimicrobial activity of a s...