We administered a biological response modifier Picibanil (OK-432), attenuated Streptococcus pyogenes, via the dorsal vein of the penis after 70% hepatectomy in rats, and clarified the scavenging effect of Picibanil on free radicals generated in the regenerating liver. A group of 5 rats was intravenously administered with 25 KE/kg of OK-432 after hepatectomy, while the control group was given sa...

Intestinal tumors were induced by repeated subcutaneous injection of 1,2-dimethylhydrazine in Donryu strain rats for 28 weeks. A streptococcal preparation, OK-432 was administered at different times of the tumor induction_ Between the OK-432 treated and the untreated groups no significant difference was observed in the incidence of intestinal tumors, the total number of tumors per rat, the loca...

در بررسی­های فونستیک سال 2011 دامنه جنوبی رشته کوه­های زاگرس ایران، یک نمونه ماده از گونه Amphipyra kautti Hacker, 2002 متعلق به خانواده Noctuidae و زیرخانواده Amphipyrinae مناطق کوهستانی استان کهگیلویه بویراحمد جمع­ آوری شناسایی شد. این که برای اولین بار ایران گزارش می­شود، همراه با ویژگی­های افتراقی، تصویر الگوی بال اندام تناسلی شده ارائه است. اطلاعات مربوط دیگر همین جنس مطالعه نیز

1. Peptoids 419 2. Oligocarbamates 420 3. Oligoureas 420 4. Vinylogous Sulfonyl Peptides 420 5. Peptidosulfonamides 420 6. Azatides 420 7. Ketides 420 D. Small Molecule Libraries 420 1. Acyclic Libraries 422 2. Libraries on Preformed Scaffolds 422 3. Heterocyclic Libraries 423 4. Structurally Heterogeneous Libraries 427 E. Cleavable Linkers 428 1. Single Cleavable Linkers 428 2. Multiply Cleava...

*1 V.E. Lashkaryov Institute of Semiconductor Physics of the National Academy of Sciences of Ukraine, 41 Nauky Ave., Kyiv 03028, Ukraine E-mail: [email protected] *2 Graduate School of Informatics, Shizuoka University, 3-5-1 Johoku, Naka-ku, Hamamatsu 432-8011, Japan *3 Research Institute of Electronics, Shizuoka University, 3-5-1 Johoku, Naka-ku, Hamamatsu 432-8011, Japan *4 ITMO University, 49 Kr...

Ten patients with advanced, unresectable carcinoma of the pancreas were treated with intratumoral high-dose injections of OK-432 and their therapeutic responses assessed from the clinical standpoint in the past four years since 1977. Following the treatment, 7 (78%) of 9 patients evaluated by the Karnofsky criteria fell under Category I, of whom 2 were classified under I-C. Five patients (50 %)...

OK-432 (a streptococcal preparation) has been widely used for cancer immunotherapy in Japan. It is the most potent immunomodulator in activating both macrophages and killer T cells and in increasing interleukin 2 production. Two K.E. (Klinische Einheit, clinical unit) of OK-432 were given intraperitoneally to each of 17 female nonobese diabetic (NOD) mice every week from 4-24 wk of age. NOD mic...

INTRODUCTION Although surgery is the treatment of choice for thyroglossal duct cysts, it can give rise to complications, including nerve injury, cyst recurrence, wound infection, and cosmetic problems. Use of a nonsurgical procedure could prevent these complications. Although simple aspiration of otolaryngological cystic diseases is a noninvasive treatment, cyst recurrence is commonly observed ...

Japanese encephalitis virus (JEV) is a plus strand RNA virus, which infects brain. MicroRNAs are regulatory non-coding RNAs which regulate the expression of various genes in cells. Viruses modulate the expression of various microRNAs to suppress anti-viral signaling and evade the immune response. SOCS (Suppressor of cytokine signalling) family of proteins are negative regulators of anti-viral J...