introduction: few studies are conducted on the efficacy of antispasmodics in the treatment of functional gastrointestinal disorders in children. we evaluated the effectiveness of a smooth-muscle relaxant (mebeverine) in the treatment of childhood functional abdominal pain (fap).   materials and methods: children (n=115, aged 6-18 years) with fap were randomized to receive mebeverine 135 mg twic...

Silver, Randi B., and Manoocher Soleimani. H1-K1-ATPases: regulation and role in pathophysiological states. Am. J. Physiol. 276 (Renal Physiol. 45): F799–F811, 1999.—Molecular cloning experiments have identified the existence of two H1-K1-ATPases (HKAs), colonic and gastric. Recent functional and molecular studies indicate the presence of both transporters in the kidney, which are presumed to m...

Friedman, Mark I., Ruth B. Harris, Hong Ji, Israel Ramirez, and Michael G. Tordoff. Fatty acid oxidation affects food intake by altering hepatic energy status. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R1046–R1053, 1999.—Inhibition of fatty acid oxidation stimulates feeding behavior in rats. To determine whether a decrease in hepatic fatty acid oxidation triggers this beha...

Borok, Zea, Salim Mihyu, Valentino F. J. Fernandes, Xiao-Ling Zhang, Kwang-Jin Kim, and Richard L. Lubman. KGF prevents hyperoxia-induced reduction of active ion transport in alveolar epithelial cells. Am. J. Physiol. 276 (Cell Physiol. 45): C1352–C1360, 1999.—We evaluated the effects of acute hyperoxic exposure on alveolar epithelial cell (AEC) active ion transport and on expression of Na1 pum...

Just, Armin, Heimo Ehmke, Uwe Wittmann, and Hartmut R. Kirchheim. Tonic and phasic influences of nitric oxide on renal blood flow autoregulation in conscious dogs. Am. J. Physiol. 276 (Renal Physiol. 45): F442–F449, 1999.—The aim of this study was to investigate the influence of the mean level and phasic modulation of NO on the dynamic autoregulation of renal blood flow (RBF). Transfer function...

Park, Choon-Ok, Xiao-Hui Xiao, and David G. Allen. Changes in intracellular Na1 and pH in rat heart during ischemia: role of Na1/H1 exchanger. Am. J. Physiol. 276 (Heart Circ. Physiol. 45): H1581–H1590, 1999.—The role of the Na1/H1 exchanger in rat hearts during ischemia and reperfusion was investigated by measurements of intracellular Na1 concentration ([Na]i) and intracellular and extracellul...

Paper 045 Military Trading ‐ A Personal Perspective DSTL/CP33384 Paper Number 45 Title of Paper ‐ Military Trading ‐ A Personal Perspective Topic ‐ No 4 Collective Endeavors Author ‐ Kate Gill, STUDENT, Defence Science and Technology Laboratory and also full time Systems EngD student at Bristol University POC ‐ Kate Gill Name of Organisation ‐ Defence Science and Technology Laboratory (DST...

Shah, N., W. S. Evans, and J. D. Veldhuis. Actions of estrogen on pulsatile, nyctohemeral, and entropic modes of growth hormone secretion. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R1351–R1358, 1999.—The neuroendocrine mechanisms by which estradiol drives growth hormone (GH) secretion in the human are poorly defined. Here we investigate estrogen’s specific regulation of th...

Matsumoto, Tetsuya, Atsuyuki Wada, Takayoshi Tsutamoto, Tomoko Omura, Hiroshi Yokohama, Masato Ohnishi, Ichiro Nakae, Masayuki Takahashi, and Masahiko Kinoshita. Vasorelaxing effects of atrial and brain natriuretic peptides on coronary circulation in heart failure. Am. J. Physiol. 276 (Heart Circ. Physiol. 45): H1935–H1942, 1999.—Natriuretic peptide (NP) receptor has been postulated to be downr...

Ladilov, Y., S. Haffner, C. Balser-Schäfer, H. Maxeiner, and H. M. Piper. Cardioprotective effects of KB-R7943: a novel inhibitor of the reverse mode of Na1/Ca21 exchanger. Am. J. Physiol. 276 (Heart Circ. Physiol. 45): H1868–H1876, 1999.—The novel inhibitor of the reverse mode of the Na1/ Ca21 exchanger (NCE) KB-R7943 (KB) was tested in isolated rat cardiomyocytes exposed to 80 min of simulate...